Hyperglycemia and Acute Pancreatitis

Completed

• Conditions: Acute Pancreatitis (AP); Diabetes Mellitus

• Registration Number: NCT06590233
• Lead Sponsor: Shanghai Changzheng Hospital

Brief Summary

The goal of this observational study is to learn about post-acute pancreatitis diabetes mellitus (PPDM-A). The main questions it aims to answer are:

1. What are the clinical characteristics of PPDM-A?

2. What are the related factors for PPDM-A?

All patients with acute pancreatitis have been given standardized treatment for the condition.

The researchers will compare the PPDM-A group with the non-PPDM-A group to find the risk factors for PPDM-A.

Detailed Description

Investigators retrospectively collected data from patients with acute pancreatitis (AP) in participating centers between January 2013 and June 2024.

Study Timeline

• Study Start: 2013-01
• Primary Completion: 2024-08
• Study Completion: 2024-08
• Study First Submitted: 2024-08-29
• Status Verified: 2024-09
• Study First Submitted QC: 2024-09-05
• Study First Posted: 2024-09-10
• Last Update Submitted: 2024-09-13
• Last Update Posted: 2024-09-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 4500

Inclusion Criteria

1. Patients with pancreatitis attending participating centers since January 2013 (patients with clinically reported AP (ICD-10:K85 or related diagnosis));
2. Age between 18 and 80 years;
3. Patients have undergone glucose metabolic tests at least 1 month after discharge from hospital.

Exclusion Criteria

1. Patients with a history of diabetes mellitus prior to the AP attack;
2. Patients who underwent pancreatic surgery;
3. Patients with hereditary pancreatitis and autoimmune pancreatitis;
4. Patients with missing data regarding age or gender.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Number of participants who have developed PPDM-A	From the AP treatment to 5 years after the end of treatment	PPDM-A was defined as diabetes after AP in the absence of a history of preexisting diabetes before the AP episode.