Assessing the Impact of Muscle Strength and Fatigability on Gait Performance Using Single Joint and Multi-joint Assessments in People With Multiple Sclerosis
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Multiple Sclerosis
- Sponsor
- Washington D.C. Veterans Affairs Medical Center
- Enrollment
- 35
- Locations
- 1
- Primary Endpoint
- Functional Ambulation Performance (FAP)
- Last Updated
- 7 years ago
Overview
Brief Summary
The purpose of this study is to compare walking to leg strength and endurance in people with multiple sclerosis (PwMS). Using these findings, we hope to be better understand what causes PwMS to have problems walking.
Detailed Description
The purposes of the research are to determine the association of gait performance with lower extremity muscle fatigability and strength measures, and create a preliminary model that can better explain the variance in gait performance based on these muscle performance values. Objective criterion-based measures of physical fatigue (i.e., fatigability) and muscle weakness have been associated with impaired task performance in people with multiple sclerosis (MS). MS-related deficits in muscle capacity result in higher fall risks and a loss of function. However, it is unclear if lower extremity fatigability tests add clinical value to objective strength testing in the rehabilitation and clinical management of MS. Better understanding how patterns of lower extremity (LE) fatigability and strength affect mobility in people with MS could improve outcome measure development and inform rehabilitation strategies.
Investigators
Michael Harris-Love
Director, 3MAP Lab, and Assoc. Director, CRC Human Performance Research Unit
Washington D.C. Veterans Affairs Medical Center
Eligibility Criteria
Inclusion Criteria
- •Age 18-85 years
- •History of multiple sclerosis
- •Expanded Disability Status Scale \< 7.0
- •Receives care at the Washington DC Veteran's Affairs Medical Center Neurology Service and Multiple Sclerosis Center of Excellence - East
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Functional Ambulation Performance (FAP)
Time Frame: 1 Day
The FAP is used to quantify self-selected gait.
Hip, knee, and ankle fatigability
Time Frame: 1 Day
For isometric tests, a exhaustion time will be calculated by determining the time that peak impulse declines to 50% using a method validated for individual with MS.
Hip, knee, and ankle maximal volitional contraction
Time Frame: 1 Day
Maximal volitional contraction will be measured by the load cell using isometric expressed as peak torque.
Secondary Outcomes
- Adult Myopathy Assessment Tool (AMAT)(1 Day)
- 5 times sit to stand test (5STS)(1 Day)