NCT01359774已完成不适用
31Phosphorus-Magnetic Resonance Spectroscopy and Huntington Disease
Institut National de la Santé Et de la Recherche Médicale, France2 个研究点 分布在 1 个国家目标入组 30 人开始时间: 2011年4月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Brain energy deficit in Huntington patients
研究概览
简要总结
The purpose of this study is to identify and quantify a brain energy deficit in Huntington patients, using 31P-RMN spectroscopy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •* 5\18 years
- •* Ability to undergo MR scanning
- •* Covered by french social security
排除标准
- •Evidence of psychiatric disorder
- •Attendant neurological disorder
- •Contraindications to MRI (claustrophobia, metallic or material implants)
- •Severe head injury
- •Unable to understand the protocol
- •Pregnancy
- •Failure to give informed consent
- •Subjects with exclusion criteria required by french law (e.g. subjects who require a legally authorized representative to obtain consent)
- •Unwillingness to be informed in case of abnormal MRI
结局指标
主要结局
Brain energy deficit in Huntington patients
时间窗: one year
31P-MRS allows quantification of high-energy phosphate metabolites such as ATP and phosphocreatine. Objective: to look at brain energy metabolism during rest and activation.
次要结局
- Correlating a brain energy deficit with (i) biochemical parameters and (ii) clinical parameters in Huntington patients(one year)
研究者
研究点 (2)
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