The Effect of Meal Composition on Blood Lipids

Not Applicable

Completed

• Conditions: Dyslipidemia
• Interventions: Other: High-Protein Condition; Other: High-Monounsaturated Fat Condition

• Registration Number: NCT02529709
• Lead Sponsor: Texas Christian University

Brief Summary

The purpose of this study is to see if a high-protein meal leads to a better postprandial (after a meal) blood lipid profile compared to a high-monounsaturated meal.

Detailed Description

The effect of a high-protein diet compared to a high-monounsaturated fat diet on fasting lipids is controversial (1,2), In addition, these studies did not examine the effect of a high-protein compared to a high-monounsaturated meal on postprandial lipid concentrations. Postprandial lipid responses are important to examine since they are associated with heart disease (3,4). In addition, most individuals in Western countries are in a postprandial state for majority of the day. The present study will compare the effect of a high-protein meal versus a high-monounsaturated fat meal on postprandial lipid responses.

Study Timeline

• Study First Submitted: 2015-08-14
• Study First Submitted QC: 2015-08-19
• Study First Posted: 2015-08-20
• Study Start: 2015-10
• Status Verified: 2016-04
• Primary Completion: 2016-04
• Study Completion: 2016-04
• Last Update Submitted: 2016-04-19
• Last Update Posted: 2016-04-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

• Men and women ages 18-65 years.

Exclusion Criteria

• Use of medications or supplements that affect lipid levels, body weight, or blood glucose,
• following a weight loss diet,
• being a vegan,
• smoking,
• heavy alcohol use,
• pregnancy,
• lactation,
• severe depression,
• eating disorders,
• presence of liver, kidney, gastrointestinal, adrenal, or untreated thyroid disease,
• diabetes,
• lactose intolerance,
• documented mal-absorption, or
• bowel surgery that affects absorption.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
High-protein meal condition	High-Protein Condition	-
High-monounsaturated fat meal condition	High-Monounsaturated Fat Condition	-

Primary Outcome Measures

Name	Time	Method
Blood lipid concentrations.	At 0 minute before the meal begins and at 30, 60, 120, and 180 minutes after the meal begins

Secondary Outcome Measures

Name	Time	Method
IL-6	At 0 minute before the meal begins and at 30, 60, 120, and 180 minutes after the meal begins
C-reactive protein	At 0 minute before the meal begins and at 30, 60, 120, and 180 minutes after the meal begins
GLP-1	At 0 minute before the meal begins and at 30, 60, 120, and 180 minutes after the meal begins
Glucose	At 0 minute before the meal begins and at 30, 60, 120, and 180 minutes after the meal begins
Insulin	At 0 minute before the meal begins and at 30, 60, 120, and 180 minutes after the meal begins
Glucagon	At 0 minute before the meal begins and at 30, 60, 120, and 180 minutes after the meal begins
TNF-α	At 0 minute before the meal begins and at 30, 60, 120, and 180 minutes after the meal begins
Leptin	At 0 minute before the meal begins and at 30, 60, 120, and 180 minutes after the meal begins

Trial Locations

Locations (1)

Texas Christian University; 🇺🇸 Fort Worth, Texas, United States