NCT02511691终止2 期
PET/MRI Imaging of Glutamate Release in the Brain of Healthy Controls
适应症
干预措施
相关药物
试验速览
- 阶段
- 2 期
- 状态
- 终止
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- Difference of Binding Potentials of 18F-PSS232 in different brain regions between Baseline PET and PET after medical challenge
研究概览
简要总结
Based on PET (18-PSS232) and MRI, glutamate release after N-acetylcystein challenge will be monitored in human brains.
详细描述
Diagnostic trial with quantification of glutamate release in PET/MR.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •healthy volunteer
排除标准
- •drug addiction
- •significant neurological or psychiatric conditions
研究组 & 干预措施
18F-PSS232
Other
Subjects receive baseline PET with 18F-PSS232 and stimulation PET with 18F-PSS232 after medical challenge with N-acetylcystein
干预措施: 18F-PSS232 (Drug)
结局指标
主要结局
Difference of Binding Potentials of 18F-PSS232 in different brain regions between Baseline PET and PET after medical challenge
时间窗: Baseline PET and PET after medical challenge will be scanned within 3 months
for details, please see Innis: Journal of Cerebral Blood Flow \& Metabolism (2007) 27, 1533-1539
次要结局
未报告次要终点
研究者
研究点 (1)
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