Effects of topical and oral corticosteroids on sinonasal microbiome

Not Applicable

Completed

• Conditions: Chronic rhinosinusitis; Infection - Other infectious diseases; Inflammatory and Immune System - Other inflammatory or immune system disorders; Respiratory - Other respiratory disorders / diseases

• Registration Number: ACTRN12619001398190
• Lead Sponsor: Associate Professor Psaltis

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2018-12-14
• Study Start: 2019-10-14
• Last Update Posted: 28 October 2019

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

Selection/inclusion criteria:
Patients who meet ALL of the following criteria will be offered inclusion in the study:
(1)Have symptoms and signs of CRS and require medical management AND
(2)are over 18 years of age AND
(3)are able to give written informed consent AND
(4)are local patients who will be returning to this centre for follow-up care

Exclusion Criteria

(1)Requirement for a specific corticosteroid or antibiotic treatment based on symptomatology
(2)allergy to steroids
(3)pregnant or breastfeeding
(4)diabetes
(5)on other CYP450 inhibiting drugs (e.g. ketoconazole, ritonavir, atazanavir, clarithromycin, indinavir, itraconazole, nefazodone, nelfinavir, saquinavir and telithromycin)
(6)liver disease

Study & Design

• Study Type: Interventional
• Study Design: Not specified