High-definition Transcranial Direct Current Stimulation for Facilitating Hand Function Recovery After Stroke
- Conditions
- Stroke
- Registration Number
- NCT03875677
- Lead Sponsor
- Chinese University of Hong Kong
- Brief Summary
Transcranial direct current stimulation (tDCS) had recently been shown having feasibility in modulating cortical excitability transiently during motor training in a noninvasive way. The findings support that tDCS and motor practice can positively promote post-stroke motor learning to improve upper-limb motor recovery after stroke. A randomized controlled trial will be conducted with three groups: HD-tDCS, conventional tDCS and sham HD-tDCS. A 10-session training will be provided to evaluate the effectiveness of transient modulation of cortical excitability through tDCS with clinical assessment scores.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 25
- Hemiparesis subsequent to first-ever unilateral stroke for more than 6 months;
- MCP and PIP finger joints can be extended to 180° passively;
- Sufficient cognition to follow the experimental instructions
- Severe hand spasticity or hand deformity;
- History of alcohol or drug abuse or epilepsy;
- Bilateral brain infarcts;
- Severe cognitive deficits;
- Comprehensive aphasia;
- Contraindications to tDCS
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Action Research Arm Test (ARAT) 3-month after the 10th session training The ARAT has total 19 items, divided into 4 categories (grasp, grip, pinch, and gross arm movement). It ranges from 3 to 0 (best to worse).
- Secondary Outcome Measures
Name Time Method Fugl-Meyer Assessment (Upper Extremity) 3-month after the 10th session training The maximum score is 66, divided into 33 items in the form of a 3-point scale (0-2), 0 is cannot perform and 2 performs fully.
Magnetic Resonance Imaging Baseline Functional magnetic resonance imaging
Wolf Motor Function Test (WMFT) 3-month after the 10th session training The WMFT measures upper limb ability through timed and functional tasks. It has 17 items, ranging from 0 to 5 (worse to best).
Trial Locations
- Locations (1)
Department of Biomedical Engineering, The Chinese University of Hong Kong
🇭🇰Shatin, Hong Kong
Department of Biomedical Engineering, The Chinese University of Hong Kong🇭🇰Shatin, Hong Kong