Effect of Anaesthesia on ER Stress in Cancer Patients

Not Applicable

Completed

• Conditions: Endoplasmic Reticulum Stress
• Interventions: Drug: Propofol; Drug: Sevoflurane

• Registration Number: NCT03561831
• Lead Sponsor: Konkuk University Medical Center

Brief Summary

Investigate the change in endoplasmic reticulum stress after cancer surgery according to different anaesthetics including propofol and sevoflurane.

Detailed Description

We hypothesize propofol and sevoflurane based anesthesia would show different pattern of endoplasmic reticulum stress after cancer surgery in patients with cancer

Study Timeline

• Study First Submitted: 2018-06-04
• Study Start: 2018-06-05
• Study First Submitted QC: 2018-06-18
• Study First Posted: 2018-06-19
• Primary Completion: 2019-05-29
• Study Completion: 2019-05-29
• Status Verified: 2021-10
• Last Update Submitted: 2021-10-14
• Last Update Posted: 2021-10-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 53

Inclusion Criteria

• patients with cancer

Exclusion Criteria

• age under 19 years old
• allergy history to propofol or sevoflurane
• history of previous cancer

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Arm && Interventions

Group	Intervention	Description
propofol group	Propofol	patients who anesthesized by propofol
sevoflurane group	Sevoflurane	patients who anesthesized by sevoflurane

Primary Outcome Measures

Name	Time	Method
Change in endoplasmic reticulum stress	baseline, postoperative 1 hours and 24 hours	Change in endoplasmic reticulum stress

Trial Locations

Locations (1)

Konkuk University Medical Center; 🇰🇷 Seoul, Korea, Republic of