Identification of the Blood Microbiota in Patient Suffering From Myocardial Infraction

Completed

• Conditions: Coronary Disease; Myocardial Infarction

• Registration Number: NCT02405468
• Lead Sponsor: University Hospital, Toulouse

Brief Summary

The investigators want to compare blood microbiota profile between patients with documented coronary lesions and patients free of coronary disease.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-07
• Study First Submitted: 2015-03-27
• Study First Submitted QC: 2015-03-31
• Study First Posted: 2015-04-01
• Primary Completion: 2015-12
• Study Completion: 2015-12
• Status Verified: 2016-02
• Last Update Submitted: 2016-02-14
• Last Update Posted: 2016-02-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 202

Inclusion Criteria

• Cases : patients who have had a myocardial infarction within one month to one year before the inclusion
• Controls : patients without history of myocardial infarction, free of coronary disease in the view of one of the following tests performed within one year before the inclusion :

Effort test Echocardiographic stress test Myocardial perfusion scintigraphy Coronarography with >= 2 major cardiovascular risk factors:

1. Treated hypertension,
2. Treated dyslipidemia
3. Current smoking
4. Diabetes mellitus

Exclusion Criteria

• Infectious disease within one week before the inclusion
• Immunocompromised patients
• Antibiotic treatment within one month before the inclusion
• Chronic viral infection
• Chronic inflammatory intestinal bowel disease
• Renal failure (estimated glomerular filtration rate< 50 ml/min//1.73 m2)
• Pregnancy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
blood bacterial 16s rDNA bacterial gene concentration	12 months	compare blood bacterial 16s rDNA bacterial gene concentration

Secondary Outcome Measures

Name	Time	Method
blood microbiota profile	12 months	compare blood microbiota profile as assessed at all taxonomic levels of interest (genus, family, order, class, phylum)

Trial Locations

Locations (1)

UHToulouse; 🇫🇷 Toulouse, France