Human Single Neuron Recordings in Epilepsy Patients

University of Birmingham1 site in 1 country20 target enrollmentFebruary 4, 2016

ConditionsEpilepsy Memory

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Epilepsy
Sponsor: University of Birmingham
Enrollment: 20
Locations: 1
Primary Endpoint: Single unit recordings
Last Updated: 6 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

This study uses single neuron recordings in pre-surgical epilepsy patients to uncover the neural mechanisms underlying memory formation and retrieval. A secondary aim is to improve diagnostic tools to identify epileptogenic tissue.

Registry

clinicaltrials.gov

Start Date

February 4, 2016

End Date

December 2021

Last Updated

6 years ago

Study Type

Interventional

Study Design

Single Group

Sex

All

Investigators

Sponsor

University of Birmingham

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Interest in participation.
•Temporal lobe epilepsy that is clinically being investigated with implantations of depth electrodes as part of the pre-surgical epilepsy monitoring.
•Cognitive/language skills sufficient to follow experimental instruction and maintain focus on the experiment.

Exclusion Criteria

•Patient does not want to participate.
•Extra-temporal epilepsy, or electrode implantation strategy that does not allow the use of micro-macrowire electrodes.
•Cognitive/language skills insufficient to follow experimental instruction and maintain focus on the experiment.

Outcomes

Primary Outcomes

Single unit recordings

Time Frame: 14 days (patient in hospital for this length of time)

Activity of individual neurons will be recorded via micro wire electrodes

Secondary Outcomes

Intracranial electroencephalogram (iEEG)(14 days (patient in hospital for this length of time))
Behavioural response data(14 days (patient in hospital for this length of time))