Phosphorous Magnetic Resonance Spectroscopy of Heart
Not Applicable
Completed
- Conditions
- Left Ventricular Dysfunction
- Interventions
- Diagnostic Test: MR Spectroscopy
- Registration Number
- NCT01110395
- Lead Sponsor
- Washington University School of Medicine
- Brief Summary
Heart needs constant supply of energy to continue working. Phosphorus magnetic resonance spectroscopy allows us to measure energy produced in the heart. The purpose of this study is to determine if the energy production is reduced in failing heart.
- Detailed Description
We will use non-invasive phosphorus magnetic resonance spectroscopy technique to measure creatine kinase (CK) flux in failing heart. The studies will be done on Siemens 3.0T human system. We will recruit subjects with LV dysfunction due to prior anterior wall myocardial infarction.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 15
Inclusion Criteria
- Individuals with left ventricular dysfunction
Exclusion Criteria
- Age < 18, pregnant, history of excessive alcohol use, or any condition (e.g. claustrophobia, a pacemaker) that would prevent him/her from completing the magnetic resonance spectroscopy study
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description MR Spectroscopy Post-Heart Transplant MR Spectroscopy Patients post heart transplant getting heart biopsy
- Primary Outcome Measures
Name Time Method An MR Spectroscopy Showing Signal to Noise Ratio to Determine the Level of Heart Failure 1-2 days
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Washington University in St. Louis
🇺🇸Saint Louis, Missouri, United States