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Phosphorous Magnetic Resonance Spectroscopy of Heart

Not Applicable
Completed
Conditions
Left Ventricular Dysfunction
Registration Number
NCT01110395
Lead Sponsor
Washington University School of Medicine
Brief Summary

Heart needs constant supply of energy to continue working. Phosphorus magnetic resonance spectroscopy allows us to measure energy produced in the heart. The purpose of this study is to determine if the energy production is reduced in failing heart.

Detailed Description

We will use non-invasive phosphorus magnetic resonance spectroscopy technique to measure creatine kinase (CK) flux in failing heart. The studies will be done on Siemens 3.0T human system. We will recruit subjects with LV dysfunction due to prior anterior wall myocardial infarction.

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
15
Inclusion Criteria
  • Individuals with left ventricular dysfunction
Exclusion Criteria
  • Age < 18, pregnant, history of excessive alcohol use, or any condition (e.g. claustrophobia, a pacemaker) that would prevent him/her from completing the magnetic resonance spectroscopy study

Study & Design

Study Type
INTERVENTIONAL
Study Design
SINGLE_GROUP
Primary Outcome Measures
NameTimeMethod
An MR Spectroscopy Showing Signal to Noise Ratio to Determine the Level of Heart Failure1-2 days
Secondary Outcome Measures
NameTimeMethod

Trial Locations

Locations (1)

Washington University in St. Louis

🇺🇸

Saint Louis, Missouri, United States

Washington University in St. Louis
🇺🇸Saint Louis, Missouri, United States

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