The comparison of the efficacy of two combined therapeutic regimens in the treatment of gastroesophageal reflux disease in term neonates
Not Applicable
- Conditions
- Gastroesophageal reflux in mature neonate.Other specified perinatal digestive system disorders
- Registration Number
- IRCT20160827029535N3
- Lead Sponsor
- Investigator
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
Healthy term neonates aged 1–30days with GERD not responding to conservative therapies including antireflux positioning, milk thickening, hypoallergic regimens and monotherapy.
Exclusion Criteria
1-Neonates with any underlying diseases, including anomalies or gastrointestinal obstruction, neurological disorders, sepsis, NEC, etc.2-Using any sedative , relaxant or anticonvulsive medications .3-History of ventilation therapy.
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The response rate of GERD symptoms and signs in each intervention group. Timepoint: One week and one month after beginning of intervention. Method of measurement: Questionnaire.
- Secondary Outcome Measures
Name Time Method The rate of complications of ranitidine , lanzoprasole and omeprazole in each group of intervention. Timepoint: One week and one month after beginning of intervention. Method of measurement: Questionnaire.