Comparing the effect of of ranitidine and pantoprazole on the occurrence of ventilated associated pneumonia
Not Applicable
- Conditions
- pneumonia.Pneumonia, unspecified
- Registration Number
- IRCT2014112611956N3
- Lead Sponsor
- Mashhad University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 180
Inclusion Criteria
Inclusion criteriona: hospitalized intubated patients in intensive care unit of Imam Reza hospital during the study. Exclusion criteria: patients showing allergic reactions to ranitidin and pantoprazol; patients with active lung disease before receiving these two drugs; patients with active gastrointestinal bleeding at the beginning of our study; immune compromised patients or the history of receiving antibiotics or any factor that changes the immune condition toward VAP.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Decreased incidance of ventilator associated pneumonia in intubated patients under mechanical ventilation. Timepoint: End of stay in the ICU. Method of measurement: Diagnostic criteria for VAP are: new infiltration in CXR plus two criteria of these three criteria:1.fever higher than 38.5,2.leukocytes more than 100000,3.pus in suctioning the tracheal tube secretion.the final diagnosis for VAP is based on the culture of the tracheal tube secretion.the existence of more than 100000 bacterial colony count will be positive.
- Secondary Outcome Measures
Name Time Method Fever more than 38.5 degree. Timepoint: Every day. Method of measurement: Thermometer.;Lekusytosis more than 10000. Timepoint: Every day. Method of measurement: CBC.;Colony count more than 100000 in tracheal tube culture. Timepoint: Every day. Method of measurement: Tracheal tube specimen culture.;New infiltration in CXR. Timepoint: Every week. Method of measurement: Chest X Ray.