Stress-associated salivary micro-RNAs.Their correlation with standard biological and psychological stress parameters in healthy individuals under standardized social stress exposure.
Not Applicable
- Conditions
- Influence of epigenetic factors of stress regulation
- Registration Number
- DRKS00010134
- Lead Sponsor
- ehrstuhl für Medizintheorie, Integrative und Anthroposophische Medizin, Institut für Integrative Medizin, Universität Witten Herdecke
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 24
Inclusion Criteria
written informed consent
- females in second half of menstrual cycle
Exclusion Criteria
- emotional instability
- necessitating treatment (i.e. pharmacological or non-pharmacological psychological treatment)
- substance abuse or addiction
- smoking
- more than 3 cups of coffee or energy drinks regulary
- females using hormonal contraceptives
- pregnancy
- ongoing breastfeeding
- stress-relaxation exercises
- cardiovaskular diseases
- skin allergy against adhesive tapes or latex products
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Can stress-related miRNAs identified in saliva exosomes (at defined times during Trier Social Stress Test (TSST)) be significantly altered in response to an acute standardized social stress exposure?
- Secondary Outcome Measures
Name Time Method Do responding miRNAs correlated with stress-associated salivary alpha-Amylase or Cortisol?<br>Do responding miRNAs correlate with stress-associated modifications of heart rate and heart rate variability (assessed by means of ECG)?<br>Do responding miRNAs correlate with psychologically perceived stress (assessed by means of VAS)?