Hemodynamic instability comparison between prazosin and amlodipine in PPGL(pheochromocytoma and paraganglioma)
Phase 4
- Conditions
- Health Condition 1: E368- Other intraoperative complicationsof endocrine system
- Registration Number
- CTRI/2024/07/071431
- Lead Sponsor
- Jawaharlal Institute of Postgraduate Medical Education and ResearchJIPMER
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1. Age- 18-65 years
2. Secretory PPGL - Elevated plasma-free meta-nephrine and or plasma-free normetanephrine irre-spective of Blood pressure recordings
3. Planned for surgical removal
Exclusion Criteria
1. Bilateral tumour
2. Distant metastasis
3. Pregnancy
4. Incapability to adhere to study protocol
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To determine the efficacy of amlodipine in reducing the intra-operative hemodynamic instability duration (%) in patients with PPGL compared to prazosinTimepoint: At the end of surgery
- Secondary Outcome Measures
Name Time Method To determine the efficacy of amlodipine in reducing the intraoperative hemodynamic instability score in patients with PPGL compared to prazosin <br/ ><br> <br/ ><br> <br/ ><br>To study Ambulatory blood pressure monitoring <br/ ><br>(ABPM ) characteristics pre-operatively & hemo-dynamic instability post-operatively in patients with PPGL <br/ ><br> <br/ ><br>To identify the factors influencing hemodynamic in-stability during the peri-operative period <br/ ><br>Timepoint: At the end of 24 hours after surgery