The longitudinal relation between hyposmia and other (non-)motor symptoms in Parkinson's disease - an observational study

Completed

• Conditions: Parkinson; Parkinson's disease; 10028037

• Registration Number: NL-OMON49039
• Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 100

Inclusion Criteria

*Included in the baseline cohort with a diagnosis of Parkinson's disease
according to the UK PD Society Brain Bank criteria
*Be able to understand the aim of the current follow-up study, understand the
study procedure and be able to give written informed consent

Exclusion Criteria

*Diagnosis changed from PD to another form of parkinsonism
*Unwillingness to be informed of unexpected medical findings
*Lack of mastery of Dutch language

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Olfactory function, measured with University of Pennsylvania Smell<br /><br>Identification Test (UPSIT)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>-disease duration (years)<br /><br>-Unified Parkinson's disease Rating Scale - motor score (UPDRS III)<br /><br>-Mini-Mental State Exam (MMSE)<br /><br>-Montreal cognitive assessment (MoCA)<br /><br>-scales for outcomes of Parkinson's disease (SCOPA)-Sleep<br /><br>-SCOPA-autonomic dysfunction<br /><br>-SCOPA-psychiatric complications<br /><br>-Beck Depression Inventory (BDI)<br /><br>-Beck Anxiety Inventory (BAI)<br /><br>-Cognitive tests: Digit Span, Stroop Color-Word test, Letter fluency, Category<br /><br>fluency, Rey's auditory Verbal Learning Test, clock drawing<br /><br>-Modified Hoehn & Yahr stage<br /><br>-Body Mass index (length/weight)<br /><br>-Blood pressure (lying down, 1 min standing, 3 min standing)<br /><br>-Medication Use (levodopa equivalent dose)</p><br>