Transfusion induced complications = transfusion associated complications ? study.
Completed
- Conditions
- The study population exists of major, non-cardiac surgery patients, who are expected to need > 3 units of red blood cell transfusions.
- Registration Number
- NL-OMON21130
- Lead Sponsor
- MC financed by the Ziekenfondsraad/ZonMW
- Brief Summary
1. BMJ 2004; 328:1281-4<br> 2. Ned Tijdschrift voor Hematologie 2005; 2:140-7
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 1548
Inclusion Criteria
Acute aneurysm-, elective aneurysm-, orthopaedic- and large gastro-intestinal surgery patients.
Exclusion Criteria
1. Under 18 years of age;
2. Transfusions received within 3 months prior to inclusion;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Postoperative:<br /><br>1. In-hospital mortality;<br /><br>2. Duration of intensive care stay.
- Secondary Outcome Measures
Name Time Method 1. Postoperative multi organ failure;<br /><br>2. Postoperative infections;<br /><br>3. Length of hospital stay;<br /><br>4. Costs/benefits of universal leukocyte depletion for the Dutch health care;<br /><br>5. Role of perioperative medication;<br /><br><br /><br /><br>Follow up <br /><br>1. Long term survival;<br /><br>2. Cancer recurrence in GI patients;<br /><br>3. Predictive role of cytokines and related genes.<br />