Pre-operative protein feeding to stimulate muscle and bone synthesis in older patients undergoing elective hip surgery*

Completed

Conditions: muscle atrophy
muscle wasting
Sarcopenia
10028302

Registration Number: NL-OMON43923

Lead Sponsor: niversiteit Maastricht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 32

Inclusion Criteria

Osteoarthritis of the hip, planned for operative treatment
Age 40-85 yr
BMI 18.5 - 35
MNA-score >17

Exclusion Criteria

- Co-morbidities and neuromuscular disorders of the lower limbs severely interacting with mobility
- Co-morbidities severely interacting with muscle metabolism of the lower limbs
- Gastrointestinal disease
- Known renal malfunction without documented approval from nephrologist)
- Known allergy to milk, milk products and soy
- Known galactosaemia

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- Muscle protein-bound L-[ring-13C6]-phenylalanine enrichments (expressed as<br /><br>MPE)<br /><br>- Bone protein-bound L-[ring-13C6]-phenylalanine enrichments (expressed as MPE)<br /><br>- Muscle tissue-free L-[ring-13C6]-phenylalanine enrichments (expressed as MPE)<br /><br>- Bone tissue-free L-[ring-13C6]-phenylalanine enrichments (expressed as MPE)<br /><br>- Plasma L-[ring-13C6]-phenylalanine enrichments (expressed as MPE) </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary endpoints will be plasma amino acid concentrations (i.e. total and<br /><br>essential amino acids, leucine, phenylalanine and albumin), and glucose, and<br /><br>insulin concentrations during surgery. </p><br>