Galactose Mediated Glycogen Resynthesis

Not Applicable

Completed

• Conditions: Exercise

• Registration Number: NCT03903861
• Lead Sponsor: University of Birmingham

Brief Summary

This study will compare short-term post-exercise muscle glycogen synthesis following combined galactose-glucose, glucose alone or galactose alone ingestion.

Detailed Description

Lactose, the sugar contained within milk, consists of glucose and galactose. Post-exercise consumption of a carbohydrate mixture containing glucose with galactose has been shown to accelerate liver glycogen repletion as compared to glucose-only provision. However, the extent to which galactose-glucose combinations influence post-exercise muscle glycogen storage has yet to be determined.

Therefore, this study will investigate whether short-term muscle glycogen storage after strenuous endurance exercise is enhanced by combined galactose-glucose or glucose only ingestion as compared to the ingestion of galactose alone.

Study Timeline

• Study First Submitted: 2019-03-29
• Study First Submitted QC: 2019-04-03
• Study First Posted: 2019-04-04
• Study Start: 2019-07-01
• Primary Completion: 2020-05-01
• Study Completion: 2020-05-01
• Status Verified: 2022-12
• Last Update Submitted: 2023-01-03
• Last Update Posted: 2023-01-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 9

Inclusion Criteria

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• Body mass index in the range: 18.5 - 27.5 kg/m2
• Participates in endurance-based exercise (e.g. cycling, running, rowing) at least 3 times per week
• Aerobic fitness: VO2max >45 ml/kg/min (men), >40 ml/kg/min (women)

Exclusion Criteria

• Lidocaine allergy
• Current participation in another scientific/clinical study
• Bleeding disorder/s
• Current or recent smoker to include vaping (last 60 days)
• Vegan
• Existence of food intolerances
• Poor recent health as indicated in the general health questionnaire
• Engage in uncommon eating practices (e.g. sustained periods of fasting)
• Diagnosed with galactosemia

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Muscle glycogen synthesis rates (mmol/kg/dm/h)	4 hours	Muscle glycogen synthesis rates over the post-exercise recovery period

Secondary Outcome Measures

Name	Time	Method
Plasma galactose (mmol/L)	Up to 6 hours	Plasma galactose during the post-exercise recovery period and during a secondary bout of exercise
Fat oxidation rates (g/min)	Up to 90 minutes	Fat oxidation during a secondary bout of exercise
Plasma glucose (mmol/L)	Up to 6 hours	Plasma glucose during the post-exercise recovery period and during a secondary bout of exercise
Carbohydrate oxidation rates (g/min)	Up to 90 minutes	Total, exogenous and endogenous carbohydrate oxidation during a secondary bout of exercise
Plasma non-esterified fatty acids (mmol/L)	Up to 6 hours	Plasma non-esterified fatty acids during the post-exercise recovery period and during a secondary bout of exercise
Plasma glycerol (umol/L)	Up to 6 hours	Plasma glycerol during the post-exercise recovery period and during a secondary bout of exercise
Serum insulin (mU/L)	Up to 6 hours	Serum insulin during the post-exercise recovery period and during a secondary bout of exercise
Plasma lactate (mmol/L)	Up to 6 hours	Plasma lactate during the post-exercise recovery period and during a secondary bout of exercise
Plasma glucagon (pmol/L)	Up to 6 hours	Plasma glucagon during the post-exercise recovery period and during a secondary bout of exercise

Trial Locations

Locations (1)

School of Sport, Exercise and Rehabilitation Sciences; 🇬🇧 Birmingham, West Midlands, United Kingdom