Intragastric pressure as a determinant of satiation.
- Conditions
- healthy volunteersno medical conditiondrugs will be studies because they are known to influence gastric motility.
- Registration Number
- EUCTR2010-022055-36-BE
- Lead Sponsor
- ZLeuven
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Recruiting
- Sex
- All
- Target Recruitment
- 20
Healthy volunteers (18-45 years) who have no bowel symptoms and who are in good general health are eligible for the study.
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) no
F.1.3.1 Number of subjects for this age range
• They have relevant underlying disease (cardia, pulmonary, metabolic, kidney or liver disease, …)
• They have a history of esophageal or gastric surgery, or recurrent or intermittent upper gastrointestinal
symptoms (upper abdominal pain, nausea, vomiting, bothersome fullness or early satiation, heartburn,
regurgitation,…)
• They have a history of allergy to several types of drugs or food.
• They have ever been treated for depression
• There is a possibility of becoming pregnant during the study period.
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Main Objective: We set out to investigate whether IGP is a determinant of satiation. To this end we plan to investigate whether:<br>1) sumatriptan reduces IGP during food intake and which effect this has on satiation (protocol 2: sumatriptan study)<br>2) erythromycine increases IGP during food intake and which effect his has on satiation (protocol 3: erythromycin study)<br>;Secondary Objective: none;Primary end point(s): liquid nutrient tolerance to reach maximum satiation
- Secondary Outcome Measures
Name Time Method