Oral and gastric contribution to satiety

Completed

Conditions: overweight and obesity
obesity
Overweight

Registration Number: NL-OMON34956

Lead Sponsor: estec

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 35

Inclusion Criteria

Male, healthy (based on subjects own judgement), age between 18 and 40 years old, BMI between 20 and 25 kg/m2, stable body weight (no changes larger than 2kg over the past month)

Exclusion Criteria

Smoking
Drug use
Use of medication
Suffering from gastrointestinal disease, diabetes, thyroid disease, endocrine disorder
Lack of appetite for any reason
DEBQ score above 2.26
Hypersensitivity to cake(ingredients)
Unsuccessful placement of the naso-gastric tube at the training visit
Intolerance to placement of the naso-gastric tube or to the intra-gastric infusion of liquid food at the training visit
Recovery of the test product after shamfeeding < 85% (dry mass) at the training visit
Pleasantness rating of the ad libitum test meal offered during training < 40 mm (100 mm VAS)
Problems with respiratory tract, such as hyperventilation, asthma or bronchitis, that can cause problems when the naso-gastric tube is inserted
Working at, or doing an MSc thesis at the Division of Human Nutrition
Currently participating or having participated in another clinical trial at the Division of Human Nutrition during the last 3 months prior to the beginning of this study

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main outcome measure is ad libitum energy intake during a lunch meal,<br /><br>served 30 minutes after the start of gastric infusion/oral stimulation. To<br /><br>measure energy intake, a pre-determined amount of sandwiches will be provided<br /><br>to the subjects. Left-overs will be weighed and chemical analyses will be<br /><br>performed to check for the actual composition and energy content.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary outcomes measures are subjective feelings of satiety that are<br /><br>measured via Visual Analogue Scale ratings. Hunger, fullness, prospective<br /><br>consumption, desire to eat, desire to eat something sweet, desire to eat<br /><br>something savoury, wellness and nauseous feelings will be rated.</p><br>