Detection of smoking related small airway dysfunction by impulse oscillometry and gas washout tests
- Conditions
- SmokingJ44.9Chronic obstructive pulmonary disease, unspecified
- Registration Number
- DRKS00005129
- Lead Sponsor
- Klinik Schillerhöhe, Robert-Bosch-Krankenhaus-GmbH,Akademisches Lehrkrankenhaus der Universität Tübingen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 136
Inclusion Criteria
healthy adults: normal spirometry
active smoker: smoking history > 10 PY and normal spirometry
ex-smoker: no smoking for 12 months, smoking history > 10 PY and normal spirometry
Exclusion Criteria
Pulmonary comorbidity,
abnormal spirometry,
Acute respiratory infection,
Pregnancy
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Significant difference of main Parameters of Impulse Oscillometry (IOS) , Nitrogen multiple breath washout (N2-MBW) and Double Tracer gas washout test with Helium and Sulfur hexafluorid (DTG-SBW) ?
- Secondary Outcome Measures
Name Time Method Association of lung function parameters (IOS, N2-MBW, DTG-SBW) with smoking history (PY)