Influence of arterial bicarbonate level on respiration control in healthy subjects

Completed

• Conditions: Regulatie ademhalingscentrum in het brein, chemosensitiviteit; chemosensitivity; Regulation of breathing centre in the brain

• Registration Number: NL-OMON41176
• Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 10

Inclusion Criteria

Informed consent
Age >18 year, <55 year
Healthy
Non-smoking
Body weight 60-80 kg

Exclusion Criteria

Pre-existent pulmonary problems
Hypo- or hyperventilation syndrome
Use of prescribed medication
BMI>35
Upper airway/esophageal/mouth or face pathology

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameter is the difference between ventilatory response with<br /><br>normal and increased bicarbonate level. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The second study parameter is the difference between electrical activity of the<br /><br>diaphragm muscle during the normal ventilatory response and after bicarbonate<br /><br>administration.<br /><br></p><br>