Characterizing tissue protein synthesis rates of non-small cell lung carcinomas in lung cancer patients

Recruiting

Conditions: carcinoma
Lung tumor
10038666

Registration Number: NL-OMON55965

Lead Sponsor: niversiteit Maastricht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 30

Inclusion Criteria

1. Aged 18-85 years
2. Compos mentis
3. Suspected lung cancer, with treatment requiring a thoracotomy or VATS
lobectomy
4. Provided written informed consent

Exclusion Criteria

1. Neoadjuvant chemo- or radiotherapy in the past four weeks
2. Use of systemic steroids in the past four week
3. Insulin-dependent diabetes mellitus
4. Pregnancy

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Lung tumor and healthy lung tissue protein synthesis rates, expressed as<br /><br>fractional synthesis rates (FSR, %/d), will be measured for 5 days prior to<br /><br>tumor resection. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The FSRs of NSCLCs will be compared between the different sizes classifications<br /><br>within the cTNM system. Furthermore, the FSRs of NSCLCs will be compared<br /><br>between the different subclassifications (i.e., adenocarcinomas, squamous cell<br /><br>carcinomas, and large cell carcinomas). In addition, correlation analysis will<br /><br>be conducted to determine whether tumor tissue protein synthesis rates are<br /><br>influenced by other patient characteristics (i.e., inflammation, lung function,<br /><br>smoking status, and smoking history). Other characterization measurements<br /><br>include hand grip strength, muscle protein synthesis rates, muscle size<br /><br>(cross-sectional area erector spinae and other muscles at L3), visceral and<br /><br>subcutaneous adipose tissue (VAT/SAT) at L3. </p><br>