Closed Loop Auditory Stimulus in Sleep and epilepsY
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Temporal Lobe Epilepsy
- Sponsor
- Cardiff and Vale University Health Board
- Enrollment
- 17
- Locations
- 1
- Primary Endpoint
- Change in Serial Reaction Time Task memory test
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
This is a single-centre pilot study of a non-invasive auditory stimulation during sleep in participants with temporal lobe epilepsy.
Detailed Description
The primary objectives will be to pilot the use of home-based auditory stimulation during sleep in 10-20 participants with temporal lobe epilepsy using wireless devices.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Participant is willing and able to give informed consent
- •Participant diagnosed with temporal lobe epilepsy
- •Will have had fewer than three generalized tonic clonic seizures per month in the last three months
- •Will be taking 3 or fewer anti-seizure medications.
- •Will have access to a computer or cellphone with an internet connection
Exclusion Criteria
- •Abnormal hearing that cannot be corrected to normal overnight.
- •Abnormal vision that cannot be corrected to normal during the day.
- •Unwilling to abstain from caffeine, alcohol, daytime naps and extreme physical exercise in the 12 hours prior to the study.
- •Cannot read English
- •Engaged in night work in the previous 2 months
- •Any history of seizures triggered by music or sounds
- •Travelled across more than 2 time zones in the last 2 months
- •Prescribed/taking sleeping tablets other than clobazam
- •Cannabis use \>4 joints/day.
Outcomes
Primary Outcomes
Change in Serial Reaction Time Task memory test
Time Frame: Baseline and following day
Does the delivery of acoustic sounds alter post-sleep preformance on the above task
Change in EEG waveform amplitude
Time Frame: 5 seconds after stimulus
Does the acoustic sound delivery alter EEG waveform amplitude of slow wave sleep
Change in Paired Associates Learning memory test
Time Frame: Baseline and following day
Does the delivery of acoustic sounds alter post-sleep preformance on the above task