NL-OMON42708
Completed
Not Applicable
Applicability of cornea confocal microscopy in the diagnosis of small fiber neuropathy. - Cornea confocal microscopy in small fiber neuropathy.
Medisch Universitair Ziekenhuis Maastricht0 sites225 target enrollmentTBD
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- small fiber neuropathie
- Sponsor
- Medisch Universitair Ziekenhuis Maastricht
- Enrollment
- 225
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Healthy subjects (n\<\=20\)
- •a. Male and female subjects of 18 years or older
- •b. One or less positive answers on the SFN\-SIQ
- •c. Written informed consent;Patients (n\<\=200\):
- •Those who are referred to our center for the analysis of possible small fiber neuropathy are eligible for participation in this study.
Exclusion Criteria
- •Healthy subjects (n\=20\)
- •\- Sensory symptoms in hands or feet or known with mono\-/polyneuropathy.
- •\- Known illnesses that can cause neuropathy, like diabetes mellitus, renal failure, alcohol abuse, rheumatoid arthritis, SLE, sarcoidosis, and thyroid dysfunction.
- •\- History of diseases of the eye such as dry eyes, atopic keratoconjunctivitis, epithelial membrane basement dystrophies, cystic corneal disorders, which all affect corneal innervation.
- •\- Patients with chronic glycemic exposure since this is a strong risk factor for corneal subbasal nerve loss.
- •\- Use of medication (also in the past) known to possibly cause polyneuropathy.;Patients (n\=200\)
- •\- History of diseases of the eye (such as mentioned above);Participants are excluded from this study when they do not want to be informed about defects or accidental findings which could be found during the pre\-screening of the ophthalmologist.
Outcomes
Primary Outcomes
Not specified
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