Corneal Confocal Microscopy: A New Diagnostic tool for Neurofibromatosis
Completed
- Conditions
- compare the corneal nerve characteristics and inflammatory cells in patient with Neurofibromatosis type 1 and 2Corneal Confocal Microscopy, Corneal Nerve, Neurofibromatosis
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
-Patients who were diagnosed by a clinician with neurofibromatosis
-Age 18-80 years old
-Can cooperate with confocal microscopy and ocular examination
Exclusion Criteria
- Participants who have a corneal abrasion, ulcer, or active corneal infection
- Participants who have ocular abnormalities that interrupt contact lens wear
- Participants with previous corneal surgery
- Participants who are allergic to topical ocular anesthesia
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Inflammatory cells and corneal nerve density Visit 0 HRT-III confocal microscopy
- Secondary Outcome Measures
Name Time Method Corneal nerve differentiation Visit 0 Compare corneal nerve density in between groups
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms link corneal nerve abnormalities to Neurofibromatosis type 1 and 2 pathogenesis?
How does corneal confocal microscopy compare to standard diagnostic methods for NF1 and NF2 in terms of sensitivity and specificity?
Are corneal nerve fiber density and inflammatory cell markers reliable biomarkers for Neurofibromatosis subtype differentiation?
What adverse events are associated with corneal confocal microscopy in NF1/NF2 patients and how are they managed?
What drug classes target neurofibromin pathways and could benefit from corneal nerve imaging as a diagnostic tool?