A study to assess the role of Oral microbiome and mucosal immunity in COVID-19 disease
Not Applicable
- Conditions
- Health Condition 1: B972- Coronavirus as the cause of diseases classified elsewhere
- Registration Number
- CTRI/2021/10/037379
- Lead Sponsor
- Department of Bio Technology
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Willing to participate and provide blood and saliva samples at stipulated time points
-Healthy Controls: No history of COVID-19, not vaccinated, negative for anti-SARS-CoV2 nucleoprotein antibodies
-Asymptomatic / symptomatic participants: NPS-positive by RT-PCR; disease severity
graded as per NIH guidelines
Exclusion Criteria
-Critically ill participants who cannot give informed consent
-Those who are not willing to get an oral examination done
-Those who cannot chew / drool to provide a SWMF sample due to severe/critical conditions
-Participants with known malignancies and pregnancies
-Participants who are on long-term immunosuppressants like those with autoimmune
diseases
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method mucosal immunity, as reflected in the oral cavity/oropharynx <br/ ><br>and the oral microbiome play a critical role in susceptibility and severity of COVID-19Timepoint: Day 0, 10-14, 30, 90
- Secondary Outcome Measures
Name Time Method mucosal immunity and the oral microbiome explains differences in mortality between similar populationsTimepoint: Day 0, 10-14, 30 and 90