Neurobehavioral Intervention as a Novel Treatment Approach for Emotion-Regulatory Deficits

Not Applicable

Completed

• Conditions: Depression; Anxiety
• Interventions: Behavioral: Computerized Neurobehavioral Intervention

• Registration Number: NCT01466751
• Lead Sponsor: Stanford University

Brief Summary

The present study will explore the effectiveness of a computer based neurobehavioral intervention in alleviating symptoms and improving emotion regulation in psychiatric populations. It will increase understanding of psychopathology at a neural-circuit level and aid development of new non-pharmacological treatment for emotion regulatory deficits.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-01
• Study First Submitted: 2011-11-03
• Study First Submitted QC: 2011-11-07
• Study First Posted: 2011-11-08
• Primary Completion: 2013-01
• Study Completion: 2013-12
• Results First Submitted: 2015-07-15
• Status Verified: 2019-03
• Results First Submitted QC: 2019-03-22
• Last Update Submitted: 2019-03-22
• Results First Posted: 2019-06-20
• Last Update Posted: 2019-06-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 28

Inclusion Criteria

• current anxiety or depression symptoms
• internet access

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Exclusion Criteria

• lifetime psychotic disorder, past-year substance dependence

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Neurobehavioral computerized tasks	Computerized Neurobehavioral Intervention	Participants will log into a personalized website and engage in computerized tasks online.
Engaging computerized tasks	Computerized Neurobehavioral Intervention	Participants will log into a personalized website and engage in computerized tasks online.

Primary Outcome Measures

Name	Time	Method
Amygdala Blood Oxygenation-level Dependent Response (BOLD) Activation to Face Affect Identification During Emotional Conflict	Baseline, 3 Months	The degree of differential BOLD signal change (T2\*-weighted contrast in a defined region of the brain as measured by functional magnetic resonance imaging) within each individual, averaged across trials, during facial affect identification (fear or happy) and induction of emotional conflict (when the emotion word "FEAR" or "HAPPY" was either congruent or incongruent with the facial expression). We examined the differential degree of amygdala BOLD signal change as a function of emotion type (fear or happy), congruency (congruent or incongruent), and hemisphere (left or right) at baseline and 3 months.
Reaction Time to Facial Affect Identification During Emotional Conflict	Baseline, 3-month	A standardized set of facial emotions (fear and happy) were presented for a duration of about 1 second in quick succession (a new face every 3-5 seconds). Across each face was written an emotional word ("FEAR" or "HAPPY"), which could be either congruent or incongruent with the facial expression. The participant was instructed to identify the facial emotion as quickly as possible and ignore the overlaid emotion word. The outcome measure of interest was the average speed (across all trials presented) within which an individual could correctly identify the facial emotion as a function of time (pre or post-intervention), treatment arm (control or intervention), facial affect (fear or happy), and congruency of word and facial affect (congruent or incongruent).

Trial Locations

Locations (1)

Stanford University, Department of Psychiatry and Behavioral Sciences; 🇺🇸 Stanford, California, United States