Effect of External Oblique Intercostal Block Versus Paravertebral Block on Postoperative Pain and Complications in Open Nephrectomy Patients

Not Applicable

Recruiting

• Conditions: Nephrectomy; Pain Scores; Paravertebral Block; External Oblique Intercostal Block
• Interventions: Drug: Bupivacaine; Drug: morphine; Drug: paracetamol; Drug: Diclofenac

• Registration Number: NCT07071012
• Lead Sponsor: Hacettepe University

Brief Summary

This study aims to compare the effects of external oblique intercostal block versus paravertebral block on postoperative pain and complications in patients undergoing open nephrectomy.

Detailed Description

Not available

Study Timeline

• Study Start: 2025-02-01
• Status Verified: 2025-07
• Study First Submitted: 2025-07-06
• Study First Submitted QC: 2025-07-08
• Study First Posted: 2025-07-17
• Last Update Submitted: 2025-07-18
• Last Update Posted: 2025-07-23
• Primary Completion: 2026-02-01
• Study Completion: 2026-02-02

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 98

Inclusion Criteria

• Aged 18 to 90 years
• Stage 2 renal cell carcinoma scheduled for open radical nephrectomy without lymph node dissection
• ASA classification I-III
• Mini-Mental State Examination score ≥24
• Provided written informed consent

Exclusion Criteria

• Neuropathy
• Hepatic failure
• Coagulopathy
• Local anesthetic allergy
• Mini-Mental State Examination score <24
• Refusal to participate

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Paravertebral block	Bupivacaine	Patients scheduled to undergo thoracic paravertebral block will receive an injection of 20 ml of 0.25% bupivacaine hydrochloride into the paravertebral space between the parietal pleura and the costotransverse ligament using a block needle under ultrasound guidance.
Paravertebral block	morphine	Patients scheduled to undergo thoracic paravertebral block will receive an injection of 20 ml of 0.25% bupivacaine hydrochloride into the paravertebral space between the parietal pleura and the costotransverse ligament using a block needle under ultrasound guidance.
Paravertebral block	paracetamol	Patients scheduled to undergo thoracic paravertebral block will receive an injection of 20 ml of 0.25% bupivacaine hydrochloride into the paravertebral space between the parietal pleura and the costotransverse ligament using a block needle under ultrasound guidance.
Paravertebral block	Diclofenac	Patients scheduled to undergo thoracic paravertebral block will receive an injection of 20 ml of 0.25% bupivacaine hydrochloride into the paravertebral space between the parietal pleura and the costotransverse ligament using a block needle under ultrasound guidance.
External Oblique Intercostal Block	Bupivacaine	Patients scheduled to undergo an external oblique intercostal block will receive an injection of 30 ml of 0.25% bupivacaine hydrochloride between the external oblique muscle and the intercostal muscle at the level of the 6th rib, using a block needle under ultrasound guidance.
External Oblique Intercostal Block	morphine	Patients scheduled to undergo an external oblique intercostal block will receive an injection of 30 ml of 0.25% bupivacaine hydrochloride between the external oblique muscle and the intercostal muscle at the level of the 6th rib, using a block needle under ultrasound guidance.
External Oblique Intercostal Block	paracetamol	Patients scheduled to undergo an external oblique intercostal block will receive an injection of 30 ml of 0.25% bupivacaine hydrochloride between the external oblique muscle and the intercostal muscle at the level of the 6th rib, using a block needle under ultrasound guidance.
External Oblique Intercostal Block	Diclofenac	Patients scheduled to undergo an external oblique intercostal block will receive an injection of 30 ml of 0.25% bupivacaine hydrochloride between the external oblique muscle and the intercostal muscle at the level of the 6th rib, using a block needle under ultrasound guidance.

Primary Outcome Measures

Name	Time	Method
Postoperative Pain Score	Up to 24 hours after surgery	Pain intensity measured using Visual Analog Scale at rest and during movement (Visual Analog Scale ranging from 0 = no pain to 10 = worst pain imaginable; higher scores indicate worse pain).

Trial Locations

Locations (1)

Hacettepe University Faculty of Medicine Hospital; 🇹🇷 Ankara, Turkey