Assessment of Blood Pressure Control and Target Organ Damage in Patients With Chronic Kidney Disease and Hypertension -II

• Conditions: Chronic Kidney Disease; Hypertension

• Registration Number: NCT02078115
• Lead Sponsor: Seoul National University Hospital

Brief Summary

The purpose of this study is to find the change of blood pressure (BP) control pattern (true controlled, white-coat, masked, and sustained uncontrolled/ dipper, non-dipper, reverse-dipper, and extreme-dipper) in patients with chronic kidney disease (CKD) over 3 years. And Other objective is the relationship between the BP control pattern and the target organ damages such as renal function, proteinuria, left ventricular hypertrophy (LVH), and so on. In addition, we will find clinical factors related to the BP control pattern.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-04
• Study First Submitted: 2014-02-05
• Status Verified: 2014-03
• Study First Submitted QC: 2014-03-03
• Last Update Submitted: 2014-03-03
• Study First Posted: 2014-03-05
• Last Update Posted: 2014-03-05
• Primary Completion: 2015-07
• Study Completion: 2015-07

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 400

Inclusion Criteria

1. with informed consent
2. 20 <= age < 75 years
3. diagnosed as hypertension 6 months (or 3 visits) prior to enrollment, taking anti-hypertensive drugs over 3 months
4. all-cause chronic kidney disease patients with 15 <= estimated GFR < 90
5. no change of anti-hypertensive drugs within 2 weeks and good compliance

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Exclusion Criteria

1. changed prescription according to ambulatory blood pressure monitoring (ABPM) regularly
2. had acute kidney injury/hospitalization
3. had a proteinuria of > 6 g/day (spot urine protein to creatinine ratio > 6.0 g/g Cr)
4. had end stage renal disease (ESRD) with dialysis and/or were a kidney recipient
5. had diseases, such as uncontrolled arrhythmia, uncontrolled bronchial asthma/chronic obstructive pulmonary disease, or primary endocrinologic diseases except diabetes mellitus
6. were pregnant/lactating women
7. were night shift workers.

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The change of blood pressure control pattern in patients with CKD	1 year after enrolling the last participant

Secondary Outcome Measures

Name	Time	Method
2) the relationship between the change of BP control pattern and the target organ damages	1 year after enrolling the last participant
3) assessment of related clinical factors with BP control pattern	1 year after enrolling the last participant
1) target organ damages in kidney and heart	1 year after enrolling the last participant

Trial Locations

Locations (1)

Seoul National University Hospital; 🇰🇷 Seoul, Korea, Republic of