NCT02078115Unknown不适用
Observational Study of Blood Pressure Control Pattern and the Impact on the Target Organ Damages
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 400
- 试验地点
- 1
- 主要终点
- The change of blood pressure control pattern in patients with CKD
研究概览
简要总结
The purpose of this study is to find the change of blood pressure (BP) control pattern (true controlled, white-coat, masked, and sustained uncontrolled/ dipper, non-dipper, reverse-dipper, and extreme-dipper) in patients with chronic kidney disease (CKD) over 3 years. And Other objective is the relationship between the BP control pattern and the target organ damages such as renal function, proteinuria, left ventricular hypertrophy (LVH), and so on. In addition, we will find clinical factors related to the BP control pattern.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 74 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •with informed consent
- •20 <= age < 75 years
- •diagnosed as hypertension 6 months (or 3 visits) prior to enrollment, taking anti-hypertensive drugs over 3 months
- •all-cause chronic kidney disease patients with 15 <= estimated GFR < 90
- •no change of anti-hypertensive drugs within 2 weeks and good compliance
排除标准
- •changed prescription according to ambulatory blood pressure monitoring (ABPM) regularly
- •had acute kidney injury/hospitalization
- •had a proteinuria of > 6 g/day (spot urine protein to creatinine ratio > 6.0 g/g Cr)
- •had end stage renal disease (ESRD) with dialysis and/or were a kidney recipient
- •had diseases, such as uncontrolled arrhythmia, uncontrolled bronchial asthma/chronic obstructive pulmonary disease, or primary endocrinologic diseases except diabetes mellitus
- •were pregnant/lactating women
- •were night shift workers.
结局指标
主要结局
The change of blood pressure control pattern in patients with CKD
时间窗: 1 year after enrolling the last participant
次要结局
- 2) the relationship between the change of BP control pattern and the target organ damages(1 year after enrolling the last participant)
- 3) assessment of related clinical factors with BP control pattern(1 year after enrolling the last participant)
- 1) target organ damages in kidney and heart(1 year after enrolling the last participant)
研究者
Yon Su Kim
Professor
Seoul National University Hospital
研究点 (1)
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