Comparison of Peripheral Venous Pressure Variation, Pulse Pressure Variation and Pleth Variability Index in Predicting Fluid Responsiveness
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Pulse Pressure Variation
- Sponsor
- Seoul National University Bundang Hospital
- Enrollment
- 150
- Locations
- 1
- Primary Endpoint
- Fluid responsiveness
- Status
- Not yet recruiting
- Last Updated
- last year
Overview
Brief Summary
Pulse pressure variation (PPV) and pleth variability index (PVI) are widely used in clinical practice as indicators of the responsiveness to fluid therapy in patients receiving mechanical ventilation. PPV, which measures changes in arterial pressure, requires arterial puncture, which is invasive, and PVI, which detects subtle changes in oxygen saturation, requires an expensive, commercial monitoring equipment. In this study, we aimed to measure peripheral venous pressure variation using less invasive waveform variation in peripheral veins and to determine whether this indicator can be clinically used to predict the responsiveness to fluid therapy. In addition, the investigators aimed to confirm the superiority of the indicators by comparing them with the responsiveness to fluid therapy of the PPV and PVI.
Detailed Description
Pulse pressure variation (PPV) and pleth variability index (PVI) are widely used in clinical practice as indicators of the responsiveness to fluid therapy. The investigators aimed to measure peripheral venous pressure variation using less invasive waveform variation in peripheral veins and to determine whether this indicator can be clinically used to predict the responsiveness to fluid therapy.
Investigators
Park InSun
Principal investigator
Seoul National University Bundang Hospital
Eligibility Criteria
Inclusion Criteria
- •Patients voluntarily agreed and signed the written informed consent form before participating in the study
- •Adults aged 19 years or older
- •American Society of Anesthesiologists physical class (ASA) 1-3
- •Patients scheduled for elective hepatectomy under general anesthesia
- •Patients who require arterial pressure monitoring and additional peripheral venous access for routine anesthesia preparation
- •Non-smokers with normal pulmonary function
Exclusion Criteria
- •Patients with abnormal findings on electrocardiogram before surgery
- •Patients who cannot undergo peripheral venous puncture
Outcomes
Primary Outcomes
Fluid responsiveness
Time Frame: intraoperative period
Cardiac output increases by more than 15% after 250 mL crystalloid injection during a fluid challenge