Comparison of Peripheral Venous Pressure Variation, Pulse Pressure Variation and Pleth Variability Index in Predicting Fluid Responsiveness
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- Fluid responsiveness
研究概览
简要总结
Pulse pressure variation (PPV) and pleth variability index (PVI) are widely used in clinical practice as indicators of the responsiveness to fluid therapy in patients receiving mechanical ventilation. PPV, which measures changes in arterial pressure, requires arterial puncture, which is invasive, and PVI, which detects subtle changes in oxygen saturation, requires an expensive, commercial monitoring equipment. In this study, we aimed to measure peripheral venous pressure variation using less invasive waveform variation in peripheral veins and to determine whether this indicator can be clinically used to predict the responsiveness to fluid therapy. In addition, the investigators aimed to confirm the superiority of the indicators by comparing them with the responsiveness to fluid therapy of the PPV and PVI.
详细描述
Pulse pressure variation (PPV) and pleth variability index (PVI) are widely used in clinical practice as indicators of the responsiveness to fluid therapy. The investigators aimed to measure peripheral venous pressure variation using less invasive waveform variation in peripheral veins and to determine whether this indicator can be clinically used to predict the responsiveness to fluid therapy.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 19 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients voluntarily agreed and signed the written informed consent form before participating in the study
- •Adults aged 19 years or older
- •American Society of Anesthesiologists physical class (ASA) 1-3
- •Patients scheduled for elective hepatectomy under general anesthesia
- •Patients who require arterial pressure monitoring and additional peripheral venous access for routine anesthesia preparation
- •Non-smokers with normal pulmonary function
排除标准
- •Patients with abnormal findings on electrocardiogram before surgery
- •Patients who cannot undergo peripheral venous puncture
结局指标
主要结局
Fluid responsiveness
时间窗: intraoperative period
Cardiac output increases by more than 15% after 250 mL crystalloid injection during a fluid challenge
次要结局
未报告次要终点
研究者
Park InSun
Principal investigator
Seoul National University Bundang Hospital