Intraoperative Pleth Variability Index (PVI) Variability
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Intraoperative Monitoring
- Sponsor
- University of California, San Francisco
- Enrollment
- 10
- Locations
- 1
- Primary Endpoint
- PVI variability
- Status
- Terminated
- Last Updated
- 5 years ago
Overview
Brief Summary
Pleth Variability Index (PVI) is a variable that is derived from photoplethysmography (PPG) signal. It is used as a surrogate for intravascular volume status intraoperatively. PVI can have significant amount of baseline variability which appears to oscillate at a very low frequency (5-10 minute cycles). This study aims to investigate the origin of these baseline oscillations.
Detailed Description
PVI is derived from the infrared photoplethysmography signal. Intraoperatively during mechanical ventilation it reflect fluid responsiveness which is a surrogate endpoint of intravascular volume. PVI signal appears to have significant baseline variability which can not be explained by rapid changes in intravascular fluid volume. The baseline PVI changes also appear to oscillate at a very low frequency, much below any previously identified spontaneous vascular oscillations. The aim of this study is to investigate weather the PVI variability originates from changes in the infrared photoplethysmography signal or if they are possibly due to the algorithm calculating PVI.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Neurosurgical patients for tumor resection
- •neurointerventional patients
- •general anesthesia with mechanical ventilation
- •communicates in english (consent)
- •over 18 years of age
Exclusion Criteria
- •unable to sign consent
- •less than 18 years of age
Outcomes
Primary Outcomes
PVI variability
Time Frame: 1 hour
PVI variability will be compare to raw infrared photoplethysmography signal