Intraoperative Pleth Variability Index (PVI) Variability
- Conditions
- Intraoperative Monitoring
- Registration Number
- NCT03215238
- Lead Sponsor
- University of California, San Francisco
- Brief Summary
Pleth Variability Index (PVI) is a variable that is derived from photoplethysmography (PPG) signal. It is used as a surrogate for intravascular volume status intraoperatively. PVI can have significant amount of baseline variability which appears to oscillate at a very low frequency (5-10 minute cycles). This study aims to investigate the origin of these baseline oscillations.
- Detailed Description
PVI is derived from the infrared photoplethysmography signal. Intraoperatively during mechanical ventilation it reflect fluid responsiveness which is a surrogate endpoint of intravascular volume.
PVI signal appears to have significant baseline variability which can not be explained by rapid changes in intravascular fluid volume. The baseline PVI changes also appear to oscillate at a very low frequency, much below any previously identified spontaneous vascular oscillations.
The aim of this study is to investigate weather the PVI variability originates from changes in the infrared photoplethysmography signal or if they are possibly due to the algorithm calculating PVI.
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 10
- Neurosurgical patients for tumor resection
- neurointerventional patients
- general anesthesia with mechanical ventilation
- communicates in english (consent)
- over 18 years of age
- unable to sign consent
- less than 18 years of age
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method PVI variability 1 hour PVI variability will be compare to raw infrared photoplethysmography signal
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
University of California San Francisco
🇺🇸San Francisco, California, United States