Food-effect study on uracil and dihydrouracil levels as a diagnostic marker of DPD activity
Completed
- Conditions
- study on markers for dihydropyrimidine dehydrogenase-activityonderzoek in gezonde vrijwilligers en geen geneesmiddelenonderzoek, dus niet specifiek betrekking op een aandoeninguracil and dihydrouracil levels as diagnostic marker
- Registration Number
- NL-OMON46108
- Lead Sponsor
- Antoni van Leeuwenhoek Ziekenhuis
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 16
Inclusion Criteria
1. Healthy volunteer; not known with cancer or current treatment for cancer
2. Age at least 18 years
3. Able and willing to give written informed consent
4. Able and willing to consume the prescribed breakfast
5. Able and willing to undergo blood sampling
Exclusion Criteria
1. Any treatment with investigational drugs within 30 days before the start of the study
2. Any condition that may interfere with the study protocol
3. Women who are pregnant
4. Allergies or intolerance for components of the prescribed breakfast
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Primary study parameters are uracil and dihydrouracil plasma levels. </p><br>
- Secondary Outcome Measures
Name Time Method <p>Not applicable. </p><br>