risk factors for infection associated kidney damage in icu patients

Phase 1

Not yet recruiting

Brief Summary: Sepsis associated acute kidney injury is a syndrome of acute loss of renal function, defined by the simultaneous presence of both Sepsis and renal dysfunction as per KDIGO criteria. Severe sepsis and septic shock are the main causes of acute kidney injury (AKI) in the intensive care unit (ICU). The treatment of AKI is supportive. No generally accepted guidelines for indication or optimal timing for initiation of renal replacement therapy (RRT) exist. Apart from life-threatening indications, the initiation of RRT is mainly based on clinical judgment.The long-term mortality of hospital survivors with AKI remains increased for several years after critical illness. Risk and outcomes for sepsis associated AKI in adult patients admitted to ICU has not been systematically evaluated. The objectives of this study is to assess the association of risk factors and outcome of ICU patients with sepsis associated AKI.

All consecutive adults admitted to ICU with suspected infection, along with SOFA score >6 or acute increase in SOFA score by >2 or culture positive sepsis will be enrolled. We will use KDIGO criteria to define AKI during ICU stay. The enrolled patients will be followed till ICU/Hospital discharge, ICU or hospital mortality, resolution of AKI, death or survival at day 90 from entry, and for long term outcome of the development of chronic kidney disease. We will collect data on multiple variables and risk factors.

Recruitment & Eligibility

Inclusion Criteria

all adult icu patients developing aki in sepsis.

Exclusion Criteria

ckd receiving dialysis organ donor or transplant patients pre existing aki at the onset of shock.

Primary Outcome Measures

Name	Time	Method
Risk factors associated SA-AKI	90 days

Secondary Outcome Measures

Name	Time	Method
resolution of AKI	ICU and hospital length of stay

Locations (1): icu, sir ganga ram hospital
🇮🇳
Central, DELHI, India
icu, sir ganga ram hospital
🇮🇳Central, DELHI, India
dr prakash shastri
Principal investigator
9810937295
prakashshastri@live.in