Ultra-low-dose Chest CT for HHT
Active, not recruiting
- Conditions
- Hereditary Hemorrhagic Telangiectasia
- Registration Number
- NCT04874558
- Lead Sponsor
- Mayo Clinic
- Brief Summary
This study aims to develop a novel ultra-low dose chest CT technology for use in Hereditary Hemorrhagic Teleangiectasia (HHT) patients and to determine the lowest possible radiation dose that is achievable without sacrificing the diagnostic quality.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 10
Inclusion Criteria
- Ages 1 to 17 years
- Diagnosed with positive HHT causing mutations or based on Curacao criteria
Exclusion Criteria
- Acute respiratory distress
- Unstable cardiovascular status
- Pneumothorax, hemoptysis
- Pulmonary edema
- Pulmonary emboli
- Fractured ribs or other chest trauma
- Recent bronchoscopy
- Lung transplantation
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Ultra-low dose images PAVM detection Baseline Number of images detecting PAVM using the ultra-low dose images (50% or lower compared to the full dose)
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie pulmonary arteriovenous malformation development in HHT patients undergoing ultra-low-dose CT screening?
How does ultra-low-dose chest CT compare to standard-dose CT in detecting PAVMs among pediatric HHT populations?
Are there specific biomarkers that correlate with PAVM severity in hereditary hemorrhagic telangiectasia for optimized imaging protocols?
What adverse events are associated with repeated ultra-low-dose CT scans in children with HHT and how can radiation exposure risks be mitigated?
What alternative diagnostic modalities or combination approaches with ultra-low-dose CT are being explored for pulmonary vascular anomaly detection in pediatric HHT patients?
Trial Locations
- Locations (1)
Mayo Clinic in Rochester
🇺🇸Rochester, Minnesota, United States
Mayo Clinic in Rochester🇺🇸Rochester, Minnesota, United States