IMPACCT: IMmune Profiling of ICU pAtients to address Chronic Critical illness and ensure healThy ageing

Imperial College London0 个研究点目标入组 600 人开始时间: 2020年9月24日最近更新: 2024年7月29日

适应症

试验速览

暂无简介。

•1. Age =18 years
•2. Admitted to an ICU for =48 hours and <120 hours (5 days)
•3. Being (or has been) treated for suspected sepsis during this ICU admission:
•3.1. Intravenous antibiotics to treat a known / suspected infection
•3.2. Acute organ dysfunction
•4. Has received organ support (any of the following):
•4.1. Respiratory – any form of mechanical ventilation, non-invasive ventilation or high-flow nasal oxygen for =24h, OR
•4.2. Cardiovascular – any intravenous continuous infusion of vasopressor or inotrope for =24h, OR
•4.3. Renal – any form of continuous renal replacement therapy for =24 or acute and new intermittent haemodialysis with at least two episodes
•5. Is expected to require ongoing care in an environment capable of providing organ support (eg and ICU or HDU) for at least one more calendar day

•1. Severe neutropenia (neutrophil count <0.5 x 10(9)/L) due to an underlying disease / treatment (but not sepsis)
•2. Corticosteroids (intravenously or oral) of more than an equivalent dose of prednisolone 0.1mg/kg for at least 7 days within the past 30 days (not as part of sepsis management)
•3. Use of therapeutic antibodies during this admission
•4. Onco-haematological disease (eg, lymphoma, leukaemia, myeloma) treated within the 5 years before inclusion
•5. Allogenic hematopoietic stem cell transplantation (regardless of timing)
•6. Chemotherapy or immunotherapy within the last 6 months prior to inclusion date
•7. Innate immune deficiency (eg, severe combined immunodeficiency)
•8. Acquired immune deficiency (eg HIV or AIDS, any stage)
•9. Receiving any other immunosuppressive therapy (eg anti-TNF therapies)
•10. Patients with a ‘withdrawal of life-sustaining treatment’ decision, at time of inclusion
•11. Moribund and not expected to survive 24 hours
•12. Participation in an interventional study of immunomodulating therapy or any other unlicensed therapy
•13. Pregnant or breastfeeding women
•14. No social security insurance (France only)
•15. Patients with restricted liberty, prisoners or under legal protection
•16. Previously enrolled in IMPACCT

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