Comparing two drugs butrophanol and butrophanol with dexmeditomedine in postoperative period with patient controlling device for abominal surgeries

Phase 1

Conditions: Health Condition 1: K928- Other specified diseases of the digestive system

Lead Sponsor: BLDEDUS SHRI BM PATIL MEDICAL COLLEGE HOSPITAL AND RESEARCH CENTER VIJAYAPUR

Recruitment & Eligibility

Inclusion Criteria

•Adult patients aged between 18-60 years of either gender for elective abdominal surgeries under General Anaesthesia.

•Patients belonging to ASA Grade Ð? and Ð?Ð? .

Exclusion Criteria

•ASA grade of >=III

•obesity [body mass index (BMI), >30]

•opioid addiction

•patients undergoing psychiatric treatment.

•uncontrolled hypertension, severe heart disease, conduction abnormality, neuropsychiatric diseases, alcohol abuse

•allergy to either Butorphanol or Dexmedetomidine.

•Pregnancy.

•If patients require rescue analgesia with in 24 h post operatively.

Primary Outcome Measures

Name	Time	Method
â?¢To study and compare the effect whendexmeditomidine is added to butorphanol for PCIA <br/ ><br>â?¢Dose requirement of butorphanol post operatively, pump press number <br/ ><br>â?¢Intraoperative and postoperative haemodynamic changes <br/ ><br>â?¢Complications like respiratory depression, nausea, vomiting, itching, bradycardia, urinary retention <br/ ><br>â?¢Patient satisfaction <br/ ><br> <br/ ><br>Timepoint: Baseline before Induction <br/ ><br>Induction <br/ ><br>Intubation <br/ ><br>30 mins post Intubation <br/ ><br>60 mins post Intubation <br/ ><br>Extubation <br/ ><br>1 h post suregy <br/ ><br>2 h post surgery <br/ ><br>6 h post surgery <br/ ><br>12 h post surgery <br/ ><br>24 h post surgery <br/ ><br> <br/ ><br> <br/ ><br>

Secondary Outcome Measures

Name	Time	Method
To study and compare the effect whendexmeditomidine is added to butorphanol for PCIA <br/ ><br>â?¢Dose requirement of butorphanol post operatively, pump press number <br/ ><br>â?¢Intraoperative and postoperative haemodynamic changes <br/ ><br>â?¢Complications like respiratory depression, nausea, vomiting, itching, bradycardia, urinary retention <br/ ><br>â?¢Patient satisfaction <br/ ><br> <br/ ><br>Timepoint: Baseline before Induction <br/ ><br>Induction <br/ ><br>Intubation <br/ ><br>30 mins post Intubation <br/ ><br>60 mins post Intubation <br/ ><br>Extubation <br/ ><br>1 h post suregy <br/ ><br>2 h post surgery <br/ ><br>6 h post surgery <br/ ><br>12 h post surgery <br/ ><br>24 h post surgery <br/ ><br> <br/ ><br> <br/ ><br>