Immune regulation in Common Variable Immunodeficiency: the role of apoptosis and regulatory T cells.
Completed
- Conditions
- defective antibody production of unknown causeprimary immunodeficiency10021460
- Registration Number
- NL-OMON32339
- Lead Sponsor
- niversitair Medisch Centrum Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 65
Inclusion Criteria
Diagnosis of CVID; based on recurrent respiratory tract infections, decreased total serum IgG (<-2SD) and impaired specific antibody production after vaccination. Both patients with and without auto immune phenomena will be included.
Diagnosis of XLA; based on the (almost complete) absence of B cells and a mutation in the Btk gene.
Exclusion Criteria
Both patients groups: uncertainty about the diagnosis. Acute and/or severe infections at the moment of inclusion.
XLA patients: existence of auto immune symptoms
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method