Study on Yanglingquan-gallbladder-central correlation based on multi-modal synchronous acquisition and fusion analysis

Not Applicable

Conditions: Cholelithiasis

Registration Number: ITMCTR1900002492

Lead Sponsor: Chengdu University of Traditional Chinese Medicine

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: All

Target Recruitment: Not specified

Inclusion Criteria

Subjects with cholelithiasis (gallstones)
(1)The diameters of gallstones in gallbladder are less than 1 cm;
(2) Right-handed;
(3) Aged between 20 to 50 years old;
(4) In the past half month, no cholecystolic and anti-infective drugs were taken, and no other clinical researchers will be involved;
(5) The informed consent is signed.
Note: Patients who meet the above five criteria can be included in this study.
Subjects after cholecystectomy
(1) Cholecystectomy (extrahepatic bile duct preservation) for cholelithiasis (intragallstone) has been performed for at least one year;
(2) No post-cholecystectomy syndrome such as epigastric or right epigastric pain, postprandial abdominal distention, dyspepsia, biliary tract infection or biliary obstruction occurred in the past three months;
(3) Right-handed persons aged between 20 to 55 years old;
(4) After physical examination, all physiological indicators are within the normal range. There are no functional or organic diseases and no head injuries in the past;
(5) No family history of mental and nervous system heredity;
(6)Subjects signed the paper version of informed consent and volunteered to participate in the experiment;
At the same time, all subjects who meet the above inclusion criteria will be considered for inclusion.
Healthy subjects:
(1) Right-handed persons aged 20 years or less than 55 years;
(2) After physical examination, all physiological indicators were in normal range. There are no functional or organic diseases and no head injury in the past;
(3) No family genetic history of mental and nervous system;
(4) Subjects signed the paper version of informed consent and volunteered to participate in the experiment.
At the same time, all healthy subjects who meet the above inclusion criteria will be considered for inclusion.

Exclusion Criteria

Subjects with cholelithiasis (gallstones)
(1) Cholelithiasis occurs in the bile duct or in the gallbladder with a diameter of more than 1 cm;
(2) Acute attack of gallbladder colic, acute cholecystitis, acute suppurative, gangrenous, obstructive cholecystitis and gallbladder perforation with diffuse peritonitis;
(3) Severe history of gastric diseases, such as peptic ulcer, upper gastrointestinal bleeding and gastric tumors;
(4) Patients with previous severe intestinal diseases, such as ulcerative colitis, Crohn's disease and irritable bowel syndrome;
(5) Patients with severe endocrine and metabolic diseases and space-occupying diseases that significantly affect the results of the study;
(6) Primary diseases and psychiatric diseases such as cardiovascular and cerebrovascular diseases, liver and kidney;
(7)Pregnant and lactating women;
(8)Those with contraindication of fMRI acquisition;
(9)Patients with severe depression and anxiety symptoms;
(10)With obvious headache, migraine, head trauma history.
Note: Patients who meet any of the above criteria will be excluded.
Subjects after cholecystectomy
(1) Pregnant or lactating women;
(2) Patients with obvious headache, migraine and head trauma history;
(3) contraindication of fMRI acquisition;
(4) Those who are participating in other clinical trials.
Note: Patients who meet any of the above criteria will be excluded.
Healthy subjects
(1) Pregnant or lactating women;
(2) Patients with history of head trauma;
(3) contraindication of fMRI;
(4) Those who are participating in other clinical trials.
Healthy subjects who meet any of the above criteria will be excluded.