The Impact of Branched-Chain Amino Acid Metabolism on Limb Dysfunction in PAD
Not Applicable
Completed
- Conditions
- Peripheral Arterial Disease
- Interventions
- Behavioral: Supervised ExerciseBehavioral: Vascular Assessment
- Registration Number
- NCT03490968
- Lead Sponsor
- Vanderbilt University Medical Center
- Brief Summary
Test the theory that abnormalities in the large blood vessels that deliver blood to your leg and the very small blood vessels in your leg's muscles (invisible to the eye) work together to worsen your leg function and walking.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 80
Inclusion Criteria
Not provided
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Exclusion Criteria
Not provided
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Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Peripheral Artery Disease (PAD) with Supervised Exercise Supervised Exercise Subjects will be referred for supervised exercise therapy. Subjects will have 3 visits per week for 12 weeks. Each visit will include a minimum of 30 to 40 minutes of exercise to improve ambulation with a certified trainer. Healthy Subjects Vascular Assessment - PAD Subjects Who Undergo Revascularization of the Leg Vascular Assessment This group of subjects are receiving leg revascularization as part of standard of care. Peripheral Artery Disease (PAD) with Supervised Exercise Vascular Assessment Subjects will be referred for supervised exercise therapy. Subjects will have 3 visits per week for 12 weeks. Each visit will include a minimum of 30 to 40 minutes of exercise to improve ambulation with a certified trainer.
- Primary Outcome Measures
Name Time Method C3/C5acylcarnitine levels in healthy control subjects. baseline C3/C5 acylcarnitine levels in PAD surgical bypass group Change from baseline to 12 weeks C3/C5acylcarnitine levels in PAD exercise group after 12 weeks Change from baseline to 12 weeks
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Vanderbilt University Medical Center
🇺🇸Nashville, Tennessee, United States