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The Impact of Branched-Chain Amino Acid Metabolism on Limb Dysfunction in PAD

Not Applicable
Completed
Conditions
Peripheral Arterial Disease
Interventions
Behavioral: Supervised Exercise
Behavioral: Vascular Assessment
Registration Number
NCT03490968
Lead Sponsor
Vanderbilt University Medical Center
Brief Summary

Test the theory that abnormalities in the large blood vessels that deliver blood to your leg and the very small blood vessels in your leg's muscles (invisible to the eye) work together to worsen your leg function and walking.

Detailed Description

Not available

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
80
Inclusion Criteria

Not provided

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Exclusion Criteria

Not provided

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Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Arm && Interventions
GroupInterventionDescription
Peripheral Artery Disease (PAD) with Supervised ExerciseSupervised ExerciseSubjects will be referred for supervised exercise therapy. Subjects will have 3 visits per week for 12 weeks. Each visit will include a minimum of 30 to 40 minutes of exercise to improve ambulation with a certified trainer.
Healthy SubjectsVascular Assessment-
PAD Subjects Who Undergo Revascularization of the LegVascular AssessmentThis group of subjects are receiving leg revascularization as part of standard of care.
Peripheral Artery Disease (PAD) with Supervised ExerciseVascular AssessmentSubjects will be referred for supervised exercise therapy. Subjects will have 3 visits per week for 12 weeks. Each visit will include a minimum of 30 to 40 minutes of exercise to improve ambulation with a certified trainer.
Primary Outcome Measures
NameTimeMethod
C3/C5acylcarnitine levels in healthy control subjects.baseline
C3/C5 acylcarnitine levels in PAD surgical bypass groupChange from baseline to 12 weeks
C3/C5acylcarnitine levels in PAD exercise group after 12 weeksChange from baseline to 12 weeks
Secondary Outcome Measures
NameTimeMethod

Trial Locations

Locations (1)

Vanderbilt University Medical Center

🇺🇸

Nashville, Tennessee, United States

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