Effect of Topical 1% Hedera helix L. Extract gel in Treatment of Primary Knee Osteoarthritis

Phase 3

Recruiting

Conditions: Knee Osteoarthritis.
Arthrosis
M15-M19

Registration Number: IRCT20110514006480N14

Lead Sponsor: Shahre-kord University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 150

Inclusion Criteria

Primary osteoarthritis in at least one knee
Having pain at least 2 weeks before treatment

Exclusion Criteria

Secondary osteoarthritis
Active liver or kidney disease, peptic ulcer, diabetes, thyroid and parathyroid diseases, and coagulation disorders
Consumed anticoagulant drugs
History of ischemic or hemorrhagic stroke or deep vein thrombosis, history of local fractures, and deformities leading to osteoarthritis and articular diseases
Allergy to any anti-inflammatory drug
Alcohol abuse, drug abuse
Used Corticosteroids of any type and other topical drugs at the site where the gel was applied, orally used other analgesics and other effective compounds for the treatment of osteoarthritis up to 10 days before beginning of the study
Pregnancy

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Severity of knee pain. Timepoint: Before as well as one, two, three, and six weeks after intervention. Method of measurement: Visual analog scale.;Morning stiffness. Timepoint: Before as well as one, two, three, and six weeks after intervention. Method of measurement: Western Ontario and McMaster Universities Osteoarthritis Index.;Daytime stiffness. Timepoint: Before as well as one, two, three, and six weeks after intervention. Method of measurement: Western Ontario and McMaster Universities Osteoarthritis Index.;Physical function. Timepoint: Before as well as one, two, three, and six weeks after intervention. Method of measurement: Western Ontario and McMaster Universities Osteoarthritis Index.

Secondary Outcome Measures