The effect of pre-operative Ramipril treatment on vascular inflammation in the abdominal aneurysm

• Conditions: An aneurysm of the abdominal aorta; MedDRA version: 8.1Level: LLTClassification code 10002882Term: Aortic aneurysm

• Registration Number: EUCTR2006-006105-86-NL
• Lead Sponsor: MC

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2006-12-12
• Last Update Posted: 19 March 2012

Recruitment & Eligibility

• Status: Authorised-recruitment may be ongoing or finished
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

Elective aneurysm repair operation
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range

Exclusion Criteria

Hypotension
Renal artery stenosis

Study & Design

• Study Type: Interventional clinical trial of medicinal product
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Main Objective: To test whether Ramipril, via its presumed effects on NFkB activation, reduces vascular inflammation in the abdominal aneurysm.;Secondary Objective: Te test whether Ramipril reduces protease activity in the abdominal aneurysm;Primary end point(s): NFkB activation in the aortic wall<br>IL-6 and 8 expression in the aortic wall