A Study to Evaluate the Efficacy and Safety of Recombinant Human Pentraxin-2 (rhPTX-2; PRM-151) in Participants With Idiopathic Pulmonary Fibrosis
- Conditions
- Idiopathic Pulmonary Fibrosis
- Interventions
- Drug: PRM-151 (Zinpentraxin Alfa)Drug: Placebo
- Registration Number
- NCT04552899
- Lead Sponsor
- Hoffmann-La Roche
- Brief Summary
This phase III study will evaluate the efficacy, safety and pharmacokinetics (PK) of recombinant human pentraxin-2 (rhPTX-2; PRM-151) zinpentraxin alfa, compared with placebo in participants with idiopathic pulmonary fibrosis (IPF).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 665
- Documented diagnosis of IPF per the 2018 American Thoracic Society (ATS)/European Respiratory Society (ERS)/Japanese Respiratory Society (JRS)/Latin American Thoracic Society (ALAT) Clinical Practice Guideline
- High-resolution computed tomography (HRCT) pattern consistent with the diagnosis of IPF, confirmed by central review of Chest HRCT and central review of any available lung biopsy (LB)
- Minimum 6 minute walk distance (6MWD) of 150 meters with maximum use of 6 L/min at sea-level and up-to 8 L/min at altitude of supplemental oxygen while maintaining oxygen saturation of greater than or equal to (>/= )83% during the 6 minute walk test (6MWT) during screening
- FVC >/= 45% predicted during screening as determined by the over-reader
- Forced expiratory volume in 1 second (FEV1)/FVC ratio greater than (>) 0.70 during screening determined by the over-reader
- Diffusing capacity for carbon monoxide (DLCO) >/= 30% and less than or equal to (</=) 90% of predicted at screening as determined by the over-reader
- If receiving pirfenidone or nintedanib treatment for IPF, the participant must have been on treatment for at least 3 months and a stable dose for at least 4 weeks prior to screening, and during screening
- If not currently receiving nintedanib or pirfenidone treatment (either treatment naïve or having previously taken and discontinued) must have discontinued such treatment >/= 4 weeks prior to screening and during screening
- Anticipated life expectancy of at least 12 months at baseline
- Participant and investigator considered all medicinal treatment options and/or possibly lung transplantation prior to considering participation in the study.
- For women of childbearing potential (excluding participant enrolling in Japan): agreement to remain abstinent or use contraception
- For men: agreement to remain abstinent or use a condom, and agreement to refrain from donating sperm
- Anticipated life expectancy of at least 12 months at baseline, according to the investigator's judgment
- For participant enrolled in the extended China enrollment phase: current resident of mainland China, Hong Kong, or Taiwan, and of Chinese ancestry
- Evidence of other known causes of Interstitial Lung Disease (ILD)
- FVC% predicted value showing repeated increase in the 6 months period prior to screening and including screening value
- Emphysema present on greater than or equal to (>/=) 50% of the HRCT, or the extent of emphysema is greater than the extent of fibrosis, according to central review of the HRCT
- Receiving nintedanib in combination with pirfenidone
- Received cytotoxic, immunosuppressive, cytokine modulating, or receptor antagonist agents (including but not limited to methotrexate, azathioprine, mycophenolate mofetil, cyclophosphamide, cyclosporine or other steroid sparing agent) within 4 weeks prior to or during screening
- Receiving systemic corticosteroids equivalent to prednisone > 10 mg/day or equivalent within 2 weeks prior to or during screening
- Acute respiratory or systemic bacterial, viral, or fungal infection either during screening or prior to screening and not successfully resolved 4 weeks prior to screening visit
- Participants with active or latent tuberculosis (confirmed within the 6 months prior to or during screening, by a positive screening test [interferon gamma release assay])
- Resting oxygen saturation of < 89% using up to 4 L/min of supplemental oxygen at sea level and up to 6 L/min at altitude (>/= 5000 feet [1524 meters] above sea level) during screening
- Class IV New York Heart Association chronic heart failure
- Historical evidence of left ventricular ejection fraction < 35%
- Presence of pulmonary hypertension that, in the investigator's opinion, would substantially limit the ability to comply with study requirements or may influence any of the safety or efficacy assessments included in the study
- Cardiopulmonary rehabilitation program based on exercise training that has been completed within 8 weeks prior to screening or planned to start during the participant enrollment in this trial
- History of smoking, alcohol or substance abuse disorder, or a malignancy
- Previous treatment with PRM-151
- Clinically significant abnormality on ECG during screening that, in the opinion of the investigator, may pose an additional risk in administering study drug to the participant including prolonged corrected QT interval > 450 ms (for men) or > 470 ms (for women) on ECG during screening based on the Fridericia correction formula
- Clinically significant laboratory test abnormalities during screening (hematology, serum chemistry, and urinalysis) that, in the opinion of the investigator, may pose an additional risk in administering study drug to the participant
- Pregnant or breastfeeding, or become pregnant during the study or within 8 weeks after the final dose of PRM-151
- Women of childbearing potential (Only for participants enrolling in Japan)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Zinpentraxin Alfa PRM-151 (Zinpentraxin Alfa) Participants will receive intravenous (IV) infusions of Zinpentraxin Alfa over 50-70 minutes on Days 1, 3 and 5, then followed by infusions every 4 weeks (Q4W) to Week 48. Placebo Placebo Participants will receive IV infusions of placebo over 50-70 minutes on Days 1, 3 and 5, followed by infusions Q4W to Week 48.
- Primary Outcome Measures
Name Time Method Absolute Change in Forced Vital Capacity (FVC [mL]) From Baseline up to Week 52
- Secondary Outcome Measures
Name Time Method Time to Disease Progression From Baseline up to 1 year Absolute Change in FVC% Predicted From Baseline up to Week 52 Survival From Baseline up to 1 year Survival is measured by all-cause mortality
Absolute Change in 6-minute Walk Distance (6MWD) From Baseline up to Week 52 Time to First Respiratory-related Hospitalizations From Baseline up to 1 year Change in Carbon Monoxide Diffusing Capacity (DLCO) At Baseline, Week 12, Week 24, Week 36 and Week 52 Plasma Concentrations of PRM-151 Days 1, 5 and Weeks 4, 12, and 24 Prevalence of Anti-drug Antibodies (ADAs) at Baseline At Baseline Percentage of Participants With Adverse Events (AEs) From Baseline up to 8 weeks after the last dose of study drug (up to an average of 1 year) Change in St. George Respiratory Questionnaire (SGRQ) Total Score At Baseline, Week 12, Week 24, Week 36 and Week 52 The SGRQ is a 50-item respiratory-specific quality-of-life questionnaire. The questions assess the impact of disease on activity, functionality and symptoms. Each scale is scored from 0-100. A total score represents the weighted average of these three subscores. A lower score indicates best health while a higher score indicates worst health.
Change in University of California, San Diego-Shortness of Breath Questionnaire (UCSD-SOBQ) At Baseline, Week 12, Week 24, Week 36 and Week 52 The UCSD-SOBQ is a 24-item questionnaire used to assess dyspnea severity during specific activities (21 items) and limitations caused by dyspnea in daily life (4 items). Items are assessed using a 6-point scale. Total scores, once summed, can range from 0-120 with a higher score reflecting greater dyspnea severity.
Time to First Acute Exacerbation of Idiopathic Pulmonary Fibrosis (IPF) From Baseline up to 1 year Percentage of Participants With Infusion-related Reactions (IRRs) and Other Adverse Events of Special Interest From Baseline up to 8 weeks after the last dose of study drug (up to an average of 1 year) Percentage of Participants Permanently Discontinuing Study Treatment Due to AEs From Baseline up to 8 weeks after the last dose of study drug (up to an average of 1 year) Percentage of Participants With ADAs During the Study Days 1, 5 and Weeks 4, 12, 24, 36, 48, 52 and 56
Trial Locations
- Locations (360)
Royal Prince Alfred Hospital
🇦🇺Camperdown, New South Wales, Australia
San Marcus Research Clinic Inc.
🇺🇸Miami, Florida, United States
University Hospitals Cleveland Medical Center
🇺🇸Cleveland, Ohio, United States
Advanced Pulmonary Research Institute
🇺🇸Loxahatchee Groves, Florida, United States
UC Irvine Medical Center
🇺🇸Orange, California, United States
Emory University
🇺🇸Atlanta, Georgia, United States
Florida Lung, Asthma and Sleep Specialists (FLASS) - Celebration
🇺🇸Celebration, Florida, United States
Lenox Hill Hospital
🇺🇸New York, New York, United States
Sarasota Memorial Health Care System; Cancer Research Program
🇺🇸Sarasota, Florida, United States
The Lung Research Center
🇺🇸Chesterfield, Missouri, United States
Indiana Univ School of Med
🇺🇸Indianapolis, Indiana, United States
Meris Clinical Research
🇺🇸Brandon, Florida, United States
Integral ? Clinical Trial Solutions
🇺🇸Weston, Florida, United States
SleepMed of South Carolina
🇺🇸Columbia, South Carolina, United States
Massachusetts General Hospital
🇺🇸Boston, Massachusetts, United States
University of Pittsburgh Medical Center
🇺🇸Pittsburgh, Pennsylvania, United States
Pulmonary & Allergy Associates
🇺🇸Summit, New Jersey, United States
Hospital Britanico de Buenos Aires
🇦🇷Ciudad Autonoma Buenos Aires, Argentina
UZ Leuven
🇧🇪Leuven, Belgium
DCOL Center for Clinical Research
🇺🇸Longview, Texas, United States
Lung Research Queensland
🇦🇺Nundah, Queensland, Australia
Pulmonix Research
🇺🇸Greensboro, North Carolina, United States
Centro de estudios respiratorios
🇦🇷Mar Del Plata, Argentina
University of Iowa Hospitals and Clinics; Investigational Drug Services
🇺🇸Iowa City, Iowa, United States
INSARES
🇦🇷Mendoza, Mendoza City, Argentina
Horizon Clinical Research Group
🇺🇸Cypress, Texas, United States
Monash Medical Centre; Medicine
🇦🇺Melbourne, Victoria, Australia
Cardiopulmonary Research Science and Technology Institute
🇺🇸Dallas, Texas, United States
University of Texas Southwestern Medical Center; Heart and Lung Clinic
🇺🇸Dallas, Texas, United States
ULB Hôpital Erasme
🇧🇪Brussels, Belgium
Piedmont Healthcare Pulmonary and Critical Care Research
🇺🇸Austell, Georgia, United States
American Health Research Inc.
🇺🇸Charlotte, North Carolina, United States
Cairns Base Hospital; Cancer Care Centre
🇦🇺Cairns, Queensland, Australia
University of Texas Medical Branch; Cardiology Department
🇺🇸Galveston, Texas, United States
Klinikum Klagenfurt am Wörthersee; 2. Medizinische Abteilung
🇦🇹Klagenfurt, Austria
Princess Alexandra Hospital
🇦🇺Woolloongabba, Queensland, Australia
Investigaciones en Patologias Respiratorias
🇦🇷San Miguel de Tucuman, Argentina
Fundacion Respirar (Centro Medico Dra. De Salvo)
🇦🇷Ciudad Autonoma Buenos Aires, Argentina
The Rhema Research Institute
🇨🇦Owen Sound, Ontario, Canada
The Queen Elizabeth Hospital
🇦🇺Adelaide, South Australia, Australia
Centre Hospitalier de l'Universite de Montreal - Notre - Dame Hos pital
🇨🇦Montreal, Quebec, Canada
Austin Hospital; Cancer Clinical Trials Centre
🇦🇺Melbourne, Victoria, Australia
University of Minnesota Medical Center
🇺🇸Minneapolis, Minnesota, United States
Bnai Zion Medical Center; Internal Medicine
🇮🇱Haifa, Israel
Evang. Lungenklinik Berlin Klinik für Pneumologie
🇩🇪Berlin, Germany
The First Affiliated Hospital of Guangzhou Medical University
🇨🇳Guangzhou, China
CHU Dijon Bourgogne Hôpital François Mitterand
🇫🇷Dijon, France
Servie de Pneumologie et centre de Transplantation Pulmonaire
🇫🇷Marseille, France
CHU Nice - Hôpital Pasteur 2
🇫🇷Nice, France
CHU de Rennes - Hopital de Pontchaillo
🇫🇷Rennes, France
Eastern Health - General Hospital
🇨🇦St. John's, Newfoundland and Labrador, Canada
Zentralklinik Bad Berka GmbH; Pneumologie
🇩🇪Bad Berka, Germany
Universitatsklinikum Essen; Innere Klinik
🇩🇪Essen, Germany
Hopital Louis Pradel
🇫🇷Bron, France
Praxis für Pneumologie Dr. Silke Mronga & Dr. Lukas Jerrentrup
🇩🇪Marburg, Germany
University of Cincinnati Cancer Institute
🇺🇸Cincinnati, Ohio, United States
IFS - Interdisziplinäres Facharztzentrum; Institut für klinische Forschung Pneumologie
🇩🇪Frankfurt am Main, Germany
Centre Hospitalier Universitaire de Reims; l'Hopital Maison Blanche
🇫🇷Reims, France
Ben-Gurion University of the Negev - Soroka University Medical Center - Pulmonology Institute
🇮🇱Beer sheva, Israel
Universitatsklinikum Gießen und Marburg GmbH
🇩🇪Gießen, Germany
Centre Hospitalier Regional Universitaire de Brest - Hopital de la Cavale Blanche
🇫🇷Brest, France
Hospital d Instructions des Armees Percy
🇫🇷Clamart, France
Centre Hospitalier Regional Universitaire de Lille
🇫🇷Lille, France
Hopital Bichat Claude Bernard; CIC
🇫🇷Paris, France
Shamir medical center
🇮🇱Be'er Ya'akov, Israel
Medizinische Hochschule Hannover; Zentrum Innere Medizin - Klinik fur Pneumologie
🇩🇪Hannover, Germany
Rambam Health Care Campus
🇮🇱Haifa, Israel
CHU de Montpellier Hopital Arnaud de Villeneuve; de Génétique
🇫🇷Montpellier, France
IKF Pneumologie Mainz Helix Medical Excellence Center Mainz
🇩🇪Mainz, Germany
Universitatsklinikum Leipzig; Apotheke
🇩🇪Leipzig, Germany
Universitätsklinikum des Saarlandes; Klinik für Augenheilkunde
🇩🇪Homburg/Saar, Germany
AORN Ospedali dei Colli Ospedale Monaldi; UOC Pneumologia ad indirizzo Oncologico
🇮🇹Napoli, Campania, Italy
Attikon University General Hospital
🇬🇷Chaidari, Greece
Debreceni Egyetem
🇭🇺Debrecen, Hungary
Meir Medical Center
🇮🇱Kfar- Saba, Israel
A.O.U. Policlinico di Modena
🇮🇹Modena, Emilia-Romagna, Italy
CHU Tours - Hôpital Bretonneau; Pharmacie
🇫🇷Tours, France
Lungenklinik Münnerstadt, Thoraxzentrum Bezirk Unterfranken
🇩🇪Münnerstadt, Germany
Thoraxklinik-Heidelberg gGmbH; Apotheke der Thoraxklinik
🇩🇪Heidelberg, Germany
Carmel Medical Center; Obstetrics and Gynecology
🇮🇱Haifa, Israel
Semmelweis University
🇭🇺Budapest, Hungary
Evangelismos Hospital; Department of Critical Care and Pulmonary Services
🇬🇷Athens, Greece
Edith Wolfson Medical Center
🇮🇱Holon, Israel
Krankenhaus Bethanien gGmbH
🇩🇪Solingen, Germany
University General Hospital of Heraklion
🇬🇷Heraklio, Greece
Markusovszky Egyetemi Oktatokorhaz ; SZEMESZET
🇭🇺Szombathely, Hungary
Tudogyogyintezet Torokbalint; Onkologiai és Jarobeteg Centrum
🇭🇺Törökbálint, Hungary
Barzilai Medical Center; Neurology Department
🇮🇱Ashkelon, Israel
Policlinico Tor Vergata - U.O.C. Malattie Apparato Respiratorio
🇮🇹Rome, Lazio, Italy
Azienda Ospedaliera Dei Colli
🇮🇹Napoli, Campania, Italy
Szent Borbala Korhaz
🇭🇺Tatabánya, Hungary
National Hospital Organization Ibarakihigashi National Hospital; Center for Clinical Research
🇯🇵Naka-gun, Japan
Kaplan Medical Center
🇮🇱Rehovot, Israel
Ospedale Morgagni Pierantoni; Patologia clinica
🇮🇹Forlì, Emilia-Romagna, Italy
Nagasaki University Hospital
🇯🇵Nagasaki, Japan
University of Padova Ca' Foncello Hospital Immunologic & Respiratory Rare Diseases Center
🇮🇹Treviso, Veneto, Italy
National Hospital Organization Kinki-Chuo Chest Medical Center
🇯🇵Sakai-shi, Japan
Università degli Studi di Napoli Federico II; Dipartimento di Scienze Oftalmologiche
🇮🇹Napoli, Campania, Italy
Azienda Sanitaria Universitaria Integrata di Trieste
🇮🇹Trieste, Friuli-Venezia Giulia, Italy
"Asst Rhodense - Unità operativa di pneumologia Ospedale ""Guido Salvini"" "
🇮🇹Garbagnate Milanese, Lombardia, Italy
Asst Santi Paolo E Carlo
🇮🇹Milano, Lombardia, Italy
National Hospital Organization Himeji Medical Center
🇯🇵Hyogo, Japan
Center Hospital of the National Center for Global Health and Medicine
🇯🇵Tokyo, Japan
The Chaim Sheba Medical Center
🇮🇱Ramat Gan, Israel
Ospedale di Ostuni - Pneumologia
🇮🇹Ostuni, Puglia, Italy
Audie L. Murphy VA Hospital, STVHCS
🇺🇸San Antonio, Texas, United States
Tokushima University Hospital
🇯🇵Tokushima, Japan
Kameda Medical Center
🇯🇵Kamogawa, Japan
Policlinico Riuniti di Foggia - Department of Medical and Surgical Sciences - University of Foggia
🇮🇹Foggia, Puglia, Italy
Tokyo Medical Ando Dentaluni Hospital Faculty of Medicine; Surgical Oncology
🇯🇵Tokyo, Japan
Kanagawa Cardiovascular and Respiratory Center
🇯🇵Kanagawa, Japan
Nippon Medical School Musashi Kosugi Hospital
🇯🇵Kawasaki-Shi, Japan
Soon Chun Hyang University Hospital Bucheon
🇰🇷Bucheon-si,, Korea, Republic of
The Catholic University of Korea Yeouido St. Mary's Hospital; Hematology-Oncology
🇰🇷Seoul, Korea, Republic of
Seoul National University Bundang Hospital
🇰🇷Seongnam-si, Korea, Republic of
Unidad Médica para la Salud Integral UMSI
🇲🇽San Nicolás de Los Garza, Nuevo LEON, Mexico
The Catholic University of Korea Seoul St. Mary?s Hospital
🇰🇷Seoul, Korea, Republic of
Auckland City Hospital
🇳🇿Auckland, New Zealand
Erasmus Medisch Centrum
🇳🇱Rotterdam, Netherlands
Centro Hospitalar Universitario Lisboa Norte - Hospital Pulido Valente
🇵🇹Lisboa, Portugal
Oslo University Hospital HF, Rikshospitalet
🇳🇴Oslo, Norway
North Manchester General Hospital
🇬🇧Manchester, United Kingdom
CMU-Beijing Chao-Yang Hospital-Beijing Institute of Respiratory Medicine
🇨🇳Beijing City, China
China-Japan Friendship Hospital
🇨🇳Beijing City, China
1st Affiliated Hospital of Zhejiang University; Clinical Trial Pharmacy
🇨🇳Hangzhou City, China
Peking University Third Hospital
🇨🇳Beijing, China
Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School
🇨🇳Nanjing City, China
China Medical University (CMU) First Affiliated Hospital
🇨🇳Shenyang City, China
Tianjin Medical University General Hospital
🇨🇳Tianjin, China
Henan University of Traditional Chinese Medicine (HUTCM) The First Affiliated Hospital
🇨🇳Zhengzhou City, China
Fiona Stanley Hospital
🇦🇺Murdoch, Western Australia, Australia
Landeskrankenhaus Salzburg; Gynäkologie Und Onkologie
🇦🇹Salzburg, Austria
Cliniques Universitaires Saint-Luc; Pharmacy
🇧🇪Bruxelles, Belgium
General Hospital of Thessaloniki G. Papanikolaou
🇬🇷Thessaloniki, Greece
Vancouver General Hospital; Gordon and Leslie Diamond Health Care
🇨🇦Vancouver, British Columbia, Canada
University Hospital of Ioannina; Pulmonology Department
🇬🇷Ioannina, Greece
Azienda Ospedaliera Papa Giovanni XXIII
🇮🇹Bergamo, Abruzzo, Italy
Athens Medical Center
🇬🇷Marousi, Greece
University General Hospital of Patras
🇬🇷Patras, Greece
Uniwersytecki Szpital Kliniczny Nr 1 im.N.Barlickiego Oddzial Kliniczny Pneumonologii i Alergologii
🇵🇱Lodz, Poland
Singapore General Hospital
🇸🇬Singapore, Singapore
Hospital Universitario Central de Asturias
🇪🇸Oviedo, Asturias, Spain
Akershus universitetssykehus
🇳🇴Lørenskog, Norway
Hospital de Santa Luzia
🇵🇹Porto, Portugal
CHVNG/E_Unidade 1; Servico de Pneumologia
🇵🇹Vila Nova de Gaia, Portugal
Azienda Ospedale Università Di Padova; Clinica Pneumologica
🇮🇹Padova, Veneto, Italy
National Cheng Kung University Hospital
🇨🇳Tainan, Taiwan
National Academy of Medical Science of Ukraine (NAMS); NRCRM
🇺🇦Kyiv, KIEV Governorate, Ukraine
Banner University Medical Center Phoenix; Main Pharmacy
🇺🇸Phoenix, Arizona, United States
Lovelace Scientific Resources, Inc.
🇺🇸Phoenix, Arizona, United States
Oregon Health and Science University
🇺🇸Portland, Oregon, United States
Vanderbilt University Medical Center
🇺🇸Nashville, Tennessee, United States
Ospedale San Giuseppe; U.O. di Pneumologia
🇮🇹Milano, Lombardia, Italy
Fondazione IRCCS Policlinico San Matteo Divisione di EmatologiaDipartimento di Onco-Ematologia
🇮🇹Pavia, Lombardia, Italy
Azienda Ospedaliera Universitaria Citta della Salute e della Scienza di Torino; Ospedale Molinette
🇮🇹Torino, Piemonte, Italy
AOUC Azienda Ospedaliero-Universitaria Careggi; Neurologia 2
🇮🇹Firenze, Toscana, Italy
Mayo Clinic Rochester
🇺🇸Rochester, Minnesota, United States
Gaziantep Universitesi - Sahinbey Arastirma ve Uygulama Hastanesi
🇹🇷Gaziantep, Turkey
Fukuoka University Hospital
🇯🇵Fukuoka, Japan
Kurashiki Central Hospital
🇯🇵Okayama, Japan
Tosei General Hospital
🇯🇵Seto-shi, Japan
University of Colorado - Anschutz Medical Campus (University of Colorado Health Sciences Center)
🇺🇸Aurora, Colorado, United States
University of South Florida
🇺🇸Tampa, Florida, United States
University of Nebraska Medical Center
🇺🇸Omaha, Nebraska, United States
Centro Medico de Enfermedades Respiratorias (CEMER)
🇦🇷Florida, Buenos Aires, Argentina
Fundacion Scherbovsky
🇦🇷Mendoza, Argentina
University of Florida Health Pulmonology - Jacksonville
🇺🇸Jacksonville, Florida, United States
University of California Davis
🇺🇸Sacramento, California, United States
University of Alabama at Birmingham
🇺🇸Birmingham, Alabama, United States
Inst. of Healthcare Assessment, Inc.
🇺🇸San Diego, California, United States
Stanford Hospital and Clinics
🇺🇸Palo Alto, California, United States
Paloma Medical Group
🇺🇸San Juan Capistrano, California, United States
UCSF Medical Center
🇺🇸San Francisco, California, United States
William Sansum Diabetes Center
🇺🇸Santa Barbara, California, United States
National Jewish Health Medical Center
🇺🇸Denver, Colorado, United States
Georgetown University Medical Center
🇺🇸Washington, District of Columbia, United States
Advanced Pulmonary & Sleep Research Institute of Florida
🇺🇸Daytona Beach, Florida, United States
Central Florida Pulmonary Group, PA
🇺🇸Orlando, Florida, United States
Renstar Medical Research
🇺🇸Ocala, Florida, United States
NorthShore University HealthSystem
🇺🇸Evanston, Illinois, United States
Clinical Site Partners Orlando
🇺🇸Winter Park, Florida, United States
Covenant Medical Center - Cooper
🇺🇸Saginaw, Michigan, United States
Brigham & Women'S Hospital
🇺🇸Boston, Massachusetts, United States
Washington University
🇺🇸Saint Louis, Missouri, United States
Duke University Medical Center
🇺🇸Durham, North Carolina, United States
PMG Research of Wilmington
🇺🇸Wilmington, North Carolina, United States
Temple University Medical Center
🇺🇸Philadelphia, Pennsylvania, United States
Jefferson University Physicians (JUP) - Jefferson Pulmonary
🇺🇸Philadelphia, Pennsylvania, United States
Mercy St. Vincent Medical Center
🇺🇸Toledo, Ohio, United States
Lowcountry Lung and Critical Care
🇺🇸North Charleston, South Carolina, United States
Metroplex Pulmonology & Sleep Center
🇺🇸McKinney, Texas, United States
University Of Utah Hosp & Clin; Investigational Pharmacy
🇺🇸Salt Lake City, Utah, United States
Inova Fairfax Hospital/IHVI; Cardiology
🇺🇸Falls Church, Virginia, United States
Instituto de Medicina Respiratoria, IMeR; Clinic/Outpatient Facility
🇦🇷Córdoba, Argentina
The Alfred Hospital
🇦🇺Prahan, Victoria, Australia
University of Alberta Hospital
🇨🇦Edmonton, Alberta, Canada
C. H. U. Sart-Tilman; Laboratory
🇧🇪Liège, Belgium
Hospital das Clinicas - UFMG
🇧🇷Belo Horizonte, MG, Brazil
CHU UCL Namur / site Godinne
🇧🇪Yvoir, Belgium
Synergy Respiratory Care
🇨🇦Sherwood Park, Alberta, Canada
Santa Casa de Misericordia de Porto Alegre
🇧🇷Porto Alegre, RS, Brazil
Kelowna Respiratory and Allergy Clinic
🇨🇦Kelowna, British Columbia, Canada
Dr. Syed Anees Medicine Profession Corporation
🇨🇦Windsor, Ontario, Canada
McGill University, Montreal Chest Institute; Viral and other Infectious
🇨🇦Montreal, Quebec, Canada
Xiangya Hospital Central South University
🇨🇳Changsha City, China
Peking Union Medical College Hospital; Pharmacy
🇨🇳Beijing City, China
Beijing Friendship Hospital Affiliated of Capital University of Medical Science
🇨🇳Beijing Shi, China
Southern Medical University Nanfang Hospital
🇨🇳Guangdong Province Guangzhou City, China
The Second Xiangya Hospital of Central South University
🇨🇳Changsha, China
The Third Xiangya Hospital Of Central South University
🇨🇳Changsha, China
West China Hospital, Sichuan University
🇨🇳Chengdu, China
The 1st Affiliated Hospital of Nanchang Unversity
🇨🇳Nanchang City, China
The First Affilicated Hospital, Sun Yat-sen University
🇨🇳Guangzhou City, China
Inner Mongolia Autonomous Region People's Hospital
🇨🇳Hohhot City, China
Qilu Hospital of Shandong University
🇨🇳Jinan, China
Ningbo First Hospital
🇨🇳Ningbo City, China
Ruijin Hospital Shanghai Jiaotong University School of Medicine
🇨🇳Shanghai City, China
Huadong Hospital Affiliated to Fudan University
🇨🇳Shanghai, China
Shengjing Hospital of China Medical University
🇨🇳ShenYang, China
Shanghai Pulmonary Hospital
🇨🇳Shanghai, China
Hebei Medical University - The Second Hospital
🇨🇳Shijiazhuang City, China
Tongji Hospital Tongji Medical College Huazhong University of Science and Technology
🇨🇳Wuhan City, China
Wuxi People's Hospital
🇨🇳Wuxi, China
Tangdu Hospital, The Fourth Military Medical University; Neurology Department
🇨🇳Xi'an City, China
The First Affiliated Hospital of Zhengzhou University
🇨🇳Zhengzhou, China
Qinghai Provincial People?s Hospital
🇨🇳Xining City, China
Fakultní Nemocnice Brno
🇨🇿Brno, Czechia
Fakultni nemocnice Olomouc
🇨🇿Olomouc, Czechia
Fakultni Nemocnice Plzen - Klinika Pneumologie a Ftizeologie
🇨🇿Plzen, Czechia
Thomayerova nemocnice; Lekarna - pavilon H
🇨🇿Praha 4, Czechia
Nemocnice Na Bulovce
🇨🇿Prague, Czechia
Aarhus Universitetshospital Skejby
🇩🇰Aarthus N, Denmark
Krajská nemocnice T. Bati, a. s.
🇨🇿Zlín, Czechia
Turku University Hospital
🇫🇮Turku, Finland
Gentofte Hospital
🇩🇰Hellerup, Denmark
Odense Universitetshospital
🇩🇰Odense C, Denmark
Hopital Avicenne
🇫🇷Bobigny, France
CHU de Grenoble - Hôpital André Michallon; Pole Pharmacie
🇫🇷La Tronche, France
Hopital Haut Leveque
🇫🇷Pessac, France
European Hospital Georges Pompidou (HEGP)
🇫🇷Paris, France
Lungenfachklinik Immenhausen
🇩🇪Immenhausen, Germany
Hospital is University General Hospital of Larissa
🇬🇷Larissa, Greece
"General hospital of Chest Diseases ""Sotiria"", 7th Pulmonary Clinic "
🇬🇷Sotiria Athens, Greece
Hadassah Medical Center
🇮🇱Jerusalem, Israel
Rabin Medical Center
🇮🇱Petach Tiqwa, Israel
Shaare Zedek Medical Center; Nrphrology Dept.
🇮🇱Jerusalem, Israel
Tel-Aviv Sourasky Medical Center; Department of Pulmonary
🇮🇱Tel Aviv, Israel
Azienda Ospedaliera Universitaria Federico II
🇮🇹Napoli, Campania, Italy
Fondazione Policlinico Universitario A Gemelli; Servizio di Farmacia
🇮🇹Rome, Lazio, Italy
A.O.U. S. Luigi Gonzaga; Interstiziopatie Malattie Rare Polmone
🇮🇹Orbassano (to), Piemonte, Italy
Ospedale San Gerardo
🇮🇹Monza, Lombardia, Italy
Azienda Ospedaliero Universitaria Ospedali Riuniti
🇮🇹Torrette Di Ancona, Marche, Italy
A.O.U. Sassari; Dip. Medicina Clinica e Sperimentale
🇮🇹Sassari, Sardegna, Italy
Azienda Ospedaliero - Universitaria Policlinico - Vittorio Emanuele
🇮🇹Catania, Sicilia, Italy
Az. Osp. Univ. P. Giaccone; UOC di Pneumologia
🇮🇹Palermo, Sicilia, Italy
Ismett Istituto Mediterraneo Trapianti E Terapie Alta Specializzazione;Pneumologia
🇮🇹Palermo, Sicilia, Italy
A.O. Univ. Senese Policlinico S. Maria alle Scotte; Dip. Medicina clinica e Scienze Immunologiche
🇮🇹Siena, Toscana, Italy
Nagoya University Hospital
🇯🇵Aichi, Japan
Chiba University Hospital
🇯🇵Chiba, Japan
National Hospital Organization Kyushu Medical Center
🇯🇵Fukuoka, Japan
Kobe City Medical Center General Hospital
🇯🇵Hyogo, Japan
Saiseikai Kumamoto Hospital
🇯🇵Kumamoto-Shi, Japan
Tenri Hospital
🇯🇵Tenri-Shi, Japan
Jichi Medical University Hospital
🇯🇵Tochigi, Japan
Gacheon University Gil Medical Center
🇰🇷Namdong-gu, Korea, Republic of
The Catholic University of Korea Bucheon St. Mary's Hospital
🇰🇷Gyeonggi-do, Korea, Republic of
Asan Medical Center
🇰🇷Seoul, Korea, Republic of
INER- Instituto Nacional de Enfermedades Respiratorias"Ismae
🇲🇽Ciudad de México, Mexico CITY (federal District), Mexico
Seoul National University Hospital (SNUH) - Medical Oncology Center
🇰🇷Seoul, Korea, Republic of
Soonchunhyang University Hospital
🇰🇷Seoul, Korea, Republic of
Centro Respiratorio de México
🇲🇽Mexico, Mexico CITY (federal District), Mexico
CICC Morelia
🇲🇽Morelia, Mexico
Unidad de Investigacion CIMA SC
🇲🇽Chihuahua, Mexico
VU Medisch Centrum
🇳🇱Amsterdam, Netherlands
Sint Antonius Ziekenhuis, locatie Nieuwegein
🇳🇱Nieuwegein, Netherlands
NZ Respiratory & Sleep Institute
🇳🇿Auckland, New Zealand
University of Otago, Christchurch
🇳🇿Christchurch, New Zealand
Tauranga Hospital
🇳🇿Tauranga, New Zealand
Waikato Hospital; Gastro Research
🇳🇿Hamilton, New Zealand
Helse Bergen HF Haukeland universitetssykehus
🇳🇴Bergen, Norway
Centrum Medycyny Oddechowej Mroz sp. j.
🇵🇱Bia?ystok, Poland
Nasz Lekarz Osrodek Badan Klinicznych
🇵🇱Bydgoszcz, Poland
Hospital de Braga; Centro Clínico Académico (Piso 1, Ala E)
🇵🇹Braga, Portugal
Centro Hospitalar Algarve
🇵🇹Faro, Portugal
Hospital Senhora da Oliveira ? Guimarães, E.P.E
🇵🇹Guimaraes, Portugal
Centro Hospitalar do Porto - Hospital de Santo António
🇵🇹Porto, Portugal
Hospital de Sao Joao; Centro de Investigacao
🇵🇹Porto, Portugal
University of Cape Town Lung Institute; Lung Clinical Research
🇿🇦Cape Town, South Africa
Tan Tock Seng Hospital; Oncology
🇸🇬Singapore, Singapore
Vergelegen Medi-Clinic
🇿🇦Somerset West, South Africa
Parc Taulí Sabadell Hospital Universitari
🇪🇸Sabadell, Barcelona, Spain
Hospital Universitario de Bellvitge
🇪🇸Hospitalet de Llobregat, Barcelona, Spain
Hospital Universitario del Henares
🇪🇸Coslada, Madrid, Spain
Complexo Hospitalario Universitario de Santiago (CHUS) - Hospital Clinico Universitario
🇪🇸Santiago de Compostela, LA Coruña, Spain
Hospital Universitario Puerta de Hierro - Majadahonda
🇪🇸Majadahonda, Madrid, Spain
Hospital Universitario de Canarias
🇪🇸S. Cristobal De La Laguna, Tenerife, Spain
Hospital de la Santa Creu i Sant Pau; Servicio de Neumologia
🇪🇸Barcelona, Spain
Universidad de Navarra - Clinica Universitaria de Navarra (CUN)
🇪🇸Pamplona, Navarra, Spain
Hospital Clinic de Barcelona
🇪🇸Barcelona, Spain
Vall d?Hebron Institute of Oncology (VHIO), Barcelona
🇪🇸Barcelona, Spain
Hospital Clinico Universitario Virgen de la Victoria
🇪🇸Malaga, Spain
Hospital Universitario de La Princesa
🇪🇸Madrid, Spain
Hospital Universitario La Paz
🇪🇸Madrid, Spain
Clínica Universidad de Navarra ? Madrid
🇪🇸Madrid, Spain
Hosp. Clinico San Carlos
🇪🇸Madrid, Spain
Hospital Universitario 12 de Octubre
🇪🇸Madrid, Spain
Hospital Universitario Fundacion Jimenez Diaz.
🇪🇸Madrid, Spain
Hospital Universitario Virgen del Rocio
🇪🇸Sevilla, Spain
Hospital Clinico Universitario de Salamanca
🇪🇸Salamanca, Spain
Hospital Clinico Universitario de Valencia
🇪🇸Valencia, Spain
Hospital Arnau de Vilanova (Valencia)
🇪🇸Valencia, Spain
Hospital Universitari i Politecnic La Fe de Valencia
🇪🇸Valencia, Spain
Skånes universitetssjukhus Malmö
🇸🇪Malmö, Sweden
Inselspital Bern Universitätsklinik für Pneumologie
🇨🇭Bern, Switzerland
Hopital Neuchatelois Pourtales (Hopitaux Cadolles Pourtales)
🇨🇭Neuchâtel, Switzerland
Buddhist Tzu Chi Dalin General Hospital; Rheumatology
🇨🇳Chia-yi, Taiwan
China Medical University Hospital
🇨🇳Taichung, Taiwan
Kaohsiung Medical University Hospital; Chung-Ho Memorial Hospital
🇨🇳Kaoshiung City, Taiwan
National Taiwan University Hospital
🇨🇳Taipei, Taiwan
Far Eastern Memorial Hospital; Department of Clinical Pathology
🇨🇳Taipei, Taiwan
Veterans General Hospital - Taichung
🇨🇳Xitun Dist., Taiwan
Istanbul Universitesi Onkoloji Enstitüsü Hastanesi
🇹🇷?stanbul, Turkey
Cukurova Universitesi Tip Fakultesi Balcali Hastanesi; Balcali
🇹🇷Adana, Turkey
Ankara Universitesi Tip Fakultesi Hastaneleri - Cebeci Hastanesi
🇹🇷Ankara, Turkey
Uludag Universitesi - Saglik Uygulama ve Arastirrma Merkezi
🇹🇷Bursa, Turkey
Yedikule Gogus Hastaliklari ve Gogus Cerrahisi EAH;Gogus Hastaliklari
🇹🇷Istanbul, Turkey
Ege Universitesi Tip Fakultesi Hastanesi
🇹🇷Izmir, Turkey
Erciyes Üniversitesi T?p Fakültesi
🇹🇷Kayseri, Turkey
Dokuz Eylul University Faculty of Medicine; Chest Diseases
🇹🇷Izmir, Turkey
Kocaeli Universitesi Tip Fakultesi
🇹🇷Kocaeli, Turkey
Mersin Üniversitesi Tip Fakültesi
🇹🇷Mersin, Turkey
Marmara Universitesi Hastanesi Marmara University Hospital
🇹🇷Maltepe, Turkey
Akdeniz University Faculty of Medicine Department of Pulmonology
🇹🇷Muratpasa/Antalya, Turkey
Municipal Non-Profit Enterprise City Clinical Hospital #16 of Dnipro City Council
🇺🇦Dnipro, Katerynoslav Governorate, Ukraine
Koc Universitesi (KU) Tip Fakultesi (Koc University School of Medicine)
🇹🇷Sariyer, Turkey
Yanovskyy Inst of Phth. & Pulm; Clinical-functional
🇺🇦Kyiv, Ukraine
Edinburgh Royal Infirmary; Respiratory Department
🇬🇧Edinburgh, United Kingdom
Royal Brompton Hospital; Respiratory Department
🇬🇧London, United Kingdom
Manchester University NHS Foundation Trust - Wythenshawe Hospital
🇬🇧Manchester, United Kingdom
Spartanburg Medical Center
🇺🇸Spartanburg, South Carolina, United States
Hospital Germans Trias i Pujol
🇪🇸Barcelona, Spain
Hospital Txagorritxu
🇪🇸Vitoria-Gasteiz, Alava, Spain
Hospital Ramón y Cajal;Servicio de Neumología
🇪🇸Madrid, Spain
Hospital Universitario Marques de Valdecilla
🇪🇸Santander, Cantabria, Spain
Hospital Universitario Quironsalud Madrid
🇪🇸Pozuelo de Alarcón, Madrid, Spain
Hospital Galdakao-Usansolo
🇪🇸Galdakao, Vizcaya, Spain
Hospital Virgen de las Nieves; Servicio de Neumologia
🇪🇸Granada, Spain
Samsung Medical Center
🇰🇷Seoul, Korea, Republic of
Korea University Guro Hospital
🇰🇷Seoul, Korea, Republic of
Yale New Haven Hospital
🇺🇸New Haven, Connecticut, United States
University of Louisville Health Sciences Center
🇺🇸Louisville, Kentucky, United States
Medical University of South Carolina Hospital
🇺🇸Charleston, South Carolina, United States
Virginia Commonwealth University
🇺🇸Richmond, Virginia, United States
University of Florida Division of Pulmonary, Critical Care, and Sleep Medicine
🇺🇸Gainesville, Florida, United States
Malcom Randall VA Medical Center
🇺🇸Gainesville, Florida, United States
University of Wisconsin-Madison
🇺🇸Madison, Wisconsin, United States
C.I.C. Mauricie
🇨🇦Trois-Rivières, Quebec, Canada
University of Kansas Medical Center
🇺🇸Kansas City, Kansas, United States
The University of Hong Kong; Queen Mary Hospital
🇭🇰Hong Kong, Hong Kong
Prince of Wales Hospital; Dept. of Medicine & Therapeutics
🇭🇰Hong Kong, Hong Kong