A Study to Evaluate Long Term Safety and Efficacy of Recombinant Human Pentraxin-2 (rhPTX-2; PRM-151) in Participants With Idiopathic Pulmonary Fibrosis
- Conditions
- Idiopathic Pulmonary Fibrosis
- Interventions
- Drug: PRM-151 (Zinpentraxin Alfa)
- Registration Number
- NCT04594707
- Lead Sponsor
- Hoffmann-La Roche
- Brief Summary
This study will evaulate the long-term safety, efficacy and pharmacokinetics (PK) of recombinant human pentraxin-2 (rhPTX-2; PRM-151) zinpentraxin alfa, administered by intravenous (IV) infusion to participants with idiopathic pulmonary fibrosis (IPF).
- Detailed Description
This study is being conducted for the treatment of eligible participants who have taken part in Study PRM-151-202 and received the open-label study drug or completed the Phase III Study WA42293 with PRM-151. Participants who have discontinued treatment from or have completed Study WA42293 and do not want to receive PRM-151 in this study, will be invited to enroll in survival follow-up.
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 117
- Taken part in either of the prior PRM-151 studies: PRM-151-202 or WA42293.
- For women of childbearing potential: agreement to remain abstinent (refrain from heterosexual intercourse) or use contraception.
- For men: agreement to remain abstinent (refrain from heterosexual intercourse) or use a condom, and agreement to refrain from donating sperm.
- Acute respiratory or systemic bacterial, viral, or fungal infection at the first visit of the OLE, or within 2 weeks of the first visit for patients joining Cohort A (from Study PRM-151-202).
- History of smoking within 3 months prior to the first visit in the OLE.
- History of alcohol or substance use disorder within 2 years prior to the first visit of the OLE or known or suspected active alcohol or substance-use disorder.
- History of severe allergic reaction or anaphylactic reaction to PRM-151.
- Clinically significant abnormality on ECG during eligibility assessment that, in the opinion of the investigator, may pose an additional risk in administering study drug to the participant.
- Prolonged corrected QT interval > 450 ms (for men) or > 470 ms (for women) based on the Fridericia correction formula.
- Clinically significant laboratory test abnormalities (hematology, serumchemistry, and urinalysis) that, in the opinion of the investigator, may pose an additional risk in administering study drug to the participant.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Zinpentraxin Alfa PRM-151 (Zinpentraxin Alfa) Corhort A: Participants entering, following participation in study PRM-151-202. Cohort B: Participants entering, following participation in study WA42293.
- Primary Outcome Measures
Name Time Method Percentage of Participants With Adverse Events (AEs) From baseline until 8 weeks after the final dose, an average of 6 months An AE was defined as any untoward medical occurrence in a clinical investigation participant who was administered a pharmaceutical product, regardless of causal attribution. Grading was completed according to the CTCAE, version 5.0.
Percentage of Participants With Infusion Related Reactions (IRRs) and Other AEs of Special Interest From baseline until 8 weeks after the final dose, an average of 6 months IRRs were defined as AEs that occurred during or within 24 hours after study drug administration and were judged to be related to study drug infusion.
Percentage of of Participants Permanently Discontinuing Study Treatment Due to AEs From baseline until 8 weeks after the final dose, an average of 6 months
- Secondary Outcome Measures
Name Time Method Annual Rate of Change in FVC% Predicted From baseline until study completion (up to approximately 1.5 years) IPF-related Mortality Every 6 Months and at study completion (up to approximately 1.5 years) Annual Rate of Change in 6-Minute Walk Distance (6MWD) From baseline until study completion (up to approximately 1.5 years) Change in Carbon Monoxide Diffusing Capacity (DLCO) At Baseline, Week 24 and Week 48 Prevalence of Anti-drug Antibodies (ADAs) to PRM-151 at Baseline Baseline (Day 1) Due to early termination of the study, only ADA samples from participants in Cohort A were analyzed.
Percentage of Participants With ADAs During the Study Weeks 4, 12 and 24 Due to early termination of the study, only ADA samples from participants in Cohort A were analyzed.
Time to Disease Progression From baseline until study completion (up to approximately 1.5 years) Time to first occurrence of \>=10% absolute decline in % predicted FVC, \>=15% relative decline in 6MWD, or death
Respiratory-related Mortality Every 6 Months and at study completion (up to approximately 1.5 years) Plasma Concentrations of PRM-151 at Specified Timepoints Days 1 and 5, Weeks 4, and 12 Due to early termination of the study, only participants enrolled in Cohort A receiving at least one IV dose of zinpentraxin alfa had their plasma concentrations analyzed.
Annual Rate of Change in Forced Vital Capacity (FVC) (mL) From baseline until study completion (up to approximately 1.5 years) Survival Every 6 Months and at study completion (up to approximately 1.5 years)
Trial Locations
- Locations (248)
Sarasota County Public Hospital
🇺🇸Sarasota, Florida, United States
NorthShore University HealthSystem
🇺🇸Evanston, Illinois, United States
Pulmonix Research
🇺🇸Greensboro, North Carolina, United States
University of Pittsburgh Medical Center
🇺🇸Pittsburgh, Pennsylvania, United States
Massachusetts General Hospital
🇺🇸Boston, Massachusetts, United States
Fondazione Policlinico Universitario A Gemelli; Servizio di Farmacia
🇮🇹Rome, Lazio, Italy
Semmelweis University
ðŸ‡ðŸ‡ºBudapest, Hungary
Centro Respiratorio de México
🇲🇽Mexico, Mexico CITY (federal District), Mexico
Nasz Lekarz Osrodek Badan Klinicznych
🇵🇱Bydgoszcz, Poland
University General Hospital of Patras
🇬🇷Patras, Greece
Vanderbilt University Medical Center
🇺🇸Nashville, Tennessee, United States
Inst. of Healthcare Assessment, Inc.
🇺🇸San Diego, California, United States
UCSF Medical Center
🇺🇸San Francisco, California, United States
University of Minnesota Medical Center
🇺🇸Minneapolis, Minnesota, United States
University Of Utah Hosp & Clin; Investigational Pharmacy
🇺🇸Salt Lake City, Utah, United States
Peking Union Medical College Hospital; Pharmacy
🇨🇳Beijing City, China
Shengjing Hospital of China Medical University
🇨🇳ShenYang, China
Hebei Medical University - The Second Hospital
🇨🇳Shijiazhuang City, China
Tongji Hospital Tongji Medical College Huazhong University of Science and Technology
🇨🇳Wuhan City, China
Wuxi People's Hospital
🇨🇳Wuxi, China
CHU Hopitaux de Bordeaux
🇫🇷CHU Hopitaux De Bordeaux, France
Centre Hospitalier Regional Universitaire de Lille
🇫🇷Lille, France
Prince of Wales Hospital; Dept. of Medicine & Therapeutics
ðŸ‡ðŸ‡°Hong Kong, Hong Kong
Debreceni Egyetem
ðŸ‡ðŸ‡ºDebrecen, Hungary
CHU Tours - Hôpital Bretonneau
🇫🇷Tours, France
Evangelismos Hospital; Endocrinology, Diabetes & Metabolism
🇬🇷Athens, Greece
Centre Hospitalier Universitaire de Rennes
🇫🇷Rennes, France
Attikon University General Hospital
🇬🇷Chaidari, Greece
University of Thessaly Faculty of Medicine
🇬🇷Mezourlo, Greece
Thoraxklinik-Heidelberg gGmbH; Apotheke der Thoraxklinik
🇩🇪Heidelberg, Germany
"General hospital of Chest Diseases ""Sotiria"", 7th Pulmonary Clinic "
🇬🇷Sotiria Athens, Greece
Rambam Health Care Campus
🇮🇱Haifa, Israel
Edith Wolfson Medical Center
🇮🇱Holon, Israel
Lungenklinik Münnerstadt, Thoraxzentrum Bezirk Unterfranken
🇩🇪Münnerstadt, Germany
Krankenhaus Bethanien gGmbH
🇩🇪Solingen, Germany
Lungenfachklinik Immenhausen
🇩🇪Immenhausen, Germany
University Hospital of Ioannina; Pulmonology Department
🇬🇷Ioannina, Greece
Shaare Zedek Medical Center
🇮🇱Jerusalem, Israel
Ben-Gurion University of the Negev - Soroka University Medical Center - Pulmonology Institute
🇮🇱Beer sheva, Israel
Athens Medical Center
🇬🇷Marousi, Greece
General Hospital of Thessaloniki G. Papanikolaou
🇬🇷Thessaloniki, Greece
Barzilai Medical Center; Neurology Department
🇮🇱Ashkelon, Israel
Shamir medical center
🇮🇱Be'er Ya'akov, Israel
Markusovszky Egyetemi Oktatokorhaz ; SZEMESZET
ðŸ‡ðŸ‡ºSzombathely, Hungary
Szent Borbala Korhaz
ðŸ‡ðŸ‡ºTatabánya, Hungary
Meir Medical Center
🇮🇱Kfar- Saba, Israel
Hadassah Medical Center
🇮🇱Jerusalem, Israel
Rabin Medical Center
🇮🇱Petach Tiqwa, Israel
The Chaim Sheba Medical Center
🇮🇱Ramat Gan, Israel
Tel Aviv Sourasky Medical Center; Department of Neurology
🇮🇱Tel Aviv, Israel
Azienda Ospedaliera Universitaria Federico II
🇮🇹Napoli, Campania, Italy
Kaplan Medical Center
🇮🇱Rehovot, Israel
Azienda Ospedaliera Papa Giovanni XXIII
🇮🇹Bergamo, Abruzzo, Italy
Kobe City Medical Center General Hospital
🇯🇵Hyogo, Japan
A.O.U. Policlinico di Modena
🇮🇹Modena, Emilia-Romagna, Italy
Policlinico Tor Vergata - U.O.C. Malattie Apparato Respiratorio
🇮🇹Rome, Lazio, Italy
"AZIENDA OSPEDALIERA DEI COLLI Monaldi-Cotugno-CTO - Pneumologia "
🇮🇹Napoli, Campania, Italy
Asst Santi Paolo E Carlo
🇮🇹Milano, Lombardia, Italy
Nippon Medical School Musashi Kosugi Hospital
🇯🇵Kawasaki-Shi, Japan
Chiba University Hospital
🇯🇵Chiba, Japan
Nagoya University Hospital
🇯🇵Aichi, Japan
National Hospital Organization Himeji Medical Center
🇯🇵Hyogo, Japan
National Hospital Organization Kyushu Medical Center
🇯🇵Fukuoka, Japan
Samsung Medical Center
🇰🇷Seoul, Korea, Republic of
Nagasaki University Hospital
🇯🇵Nagasaki, Japan
Tosei General Hospital
🇯🇵Seto-shi, Japan
Seoul National University Bundang Hospital
🇰🇷Seongnam-si, Korea, Republic of
National Hospital Organization Ibarakihigashi National Hospital; Center for Clinical Research
🇯🇵Naka-gun, Japan
Tokushima University Hospital
🇯🇵Tokushima, Japan
The Catholic University of Korea Yeouido St. Mary's Hospital; Hematology-Oncology
🇰🇷Seoul, Korea, Republic of
Korea University Guro Hospital
🇰🇷Seoul, Korea, Republic of
CICC Morelia
🇲🇽Morelia, Mexico
CHVNG/E_Unidade 1; Servico de Pneumologia
🇵🇹Vila Nova de Gaia, Portugal
Sint Antonius Ziekenhuis, locatie Nieuwegein
🇳🇱Nieuwegein, Netherlands
National University Hospital
🇸🇬Singapore, Singapore
Tan Tock Seng Hospital; Oncology
🇸🇬Singapore, Singapore
Erasmus Medisch Centrum
🇳🇱Rotterdam, Netherlands
Auckland City Hospital
🇳🇿Auckland, New Zealand
Hospital de Braga; Centro ClÃnico Académico (Piso 1, Ala E)
🇵🇹Braga, Portugal
University of Otago, Christchurch
🇳🇿Christchurch, New Zealand
Centro Hospitalar do Alto Ave; EPE
🇵🇹Guimarães, Portugal
Tauranga Hospital
🇳🇿Tauranga, New Zealand
HUA - Txagorritxu
🇪🇸Vitoria, Alava, Spain
Singapore General Hospital
🇸🇬Singapore, Singapore
University of Cape Town Lung Institute; Lung Clinical Research
🇿🇦Cape Town, South Africa
Vergelegen Medi-Clinic
🇿🇦Somerset West, South Africa
Hospital Univ. Central de Asturias
🇪🇸Oviedo, Asturias, Spain
Hospital Universitario Marques de Valdecilla
🇪🇸Santander, Cantabria, Spain
Hospital Virgen de las Nieves; Servicio de Neumologia
🇪🇸Granada, Spain
CHUS H Clinico U de Santiago
🇪🇸Santiago de Compostela, LA Coruña, Spain
Hospital Germans Trias i Pujol
🇪🇸Barcelona, Spain
Fundacion Jimenez Diaz-UTE
🇪🇸Madrid, Spain
Hospital de la Santa Creu i Sant Pau; Servicio de Neumologia
🇪🇸Barcelona, Spain
Hospital Universitario de la Princesa; Servicio de Aparato Digestivo
🇪🇸Madrid, Spain
Hospital Ramón y Cajal;Servicio de NeumologÃa
🇪🇸Madrid, Spain
Kaohsiung Medical University Hospital; Chung-Ho Memorial Hospital
🇨🇳Kaoshiung City, Taiwan
Hospital Clinico Universitario Virgen de la Victoria
🇪🇸Malaga, Spain
Hospital Clinico Universitario de Valencia
🇪🇸Valencia, Spain
Veterans General Hospital - Taichung
🇨🇳Xitun Dist., Taiwan
Dokuz Eylul University Faculty of Medicine; Chest Diseases
🇹🇷Izmir, Turkey
Kocaeli Universitesi Tip Fakultesi
🇹🇷Kocaeli, Turkey
Koc Universitesi (KU) Tip Fakultesi (Koc University School of Medicine)
🇹🇷Sariyer, Turkey
Meris Clinical Research
🇺🇸Brandon, Florida, United States
Advanced Pulmonary Research Institute
🇺🇸Loxahatchee Groves, Florida, United States
Washington University
🇺🇸Saint Louis, Missouri, United States
PMG Research of Wilmington
🇺🇸Wilmington, North Carolina, United States
The Lung Research Center
🇺🇸Chesterfield, Missouri, United States
University of Iowa Hospitals and Clinics; Investigational Drug Services
🇺🇸Iowa City, Iowa, United States
University of Texas Medical Branch at Galveston
🇺🇸Galveston, Texas, United States
Inova Fairfax Hospital
🇺🇸Falls Church, Virginia, United States
Lenox Hill Hospital
🇺🇸New York, New York, United States
Lowcountry Lung and Critical Care
🇺🇸North Charleston, South Carolina, United States
Spartanburg Medical Center
🇺🇸Spartanburg, South Carolina, United States
Jefferson University Physicians (JUP) - Jefferson Pulmonary
🇺🇸Philadelphia, Pennsylvania, United States
SleepMed of South Carolina
🇺🇸Columbia, South Carolina, United States
Metroplex Pulmonology & Sleep Center
🇺🇸McKinney, Texas, United States
Hospital Universitario Austral
🇦🇷Derqui-Pilar, Argentina
INSARES
🇦🇷Mendoza, Mendoza City, Argentina
C. H. U. Sart-Tilman; Laboratory
🇧🇪Liège, Belgium
CHU UCL Namur / site Godinne
🇧🇪Yvoir, Belgium
Hospital Britanico de Buenos Aires
🇦🇷Ciudad Autonoma Buenos Aires, Argentina
Fundacion Scherbovsky
🇦🇷Mendoza, Argentina
Instituto de Medicina Respiratoria, IMeR; Clinic/Outpatient Facility
🇦🇷Córdoba, Argentina
Royal Prince Alfred Hospital
🇦🇺Camperdown, New South Wales, Australia
Instituto Medico de la Fundacion Estudios Clinicos
🇦🇷Rosario, Argentina
Centro Medico de Enfermedades Respiratorias (CEMER)
🇦🇷Florida, Buenos Aires, Argentina
Investigaciones en Patologias Respiratorias
🇦🇷San Miguel de Tucuman, Argentina
Monash Medical Centre; Medicine
🇦🇺Melbourne, Victoria, Australia
Synergy Respiratory Care
🇨🇦Sherwood Park, Alberta, Canada
Centre Hospitalier Universitaire de Reims; l'Hopital Maison Blanche
🇫🇷Reims, France
Kelowna Respiratory and Allergy Clinic
🇨🇦Kelowna, British Columbia, Canada
Krajska nemocnice T. Bati a.s.; Neurologicke oddeleni
🇨🇿Zlin, Czechia
Evang. Lungenklinik Berlin Klinik für Pneumologie
🇩🇪Berlin, Germany
The Rhema Research Institute
🇨🇦Owen Sound, Ontario, Canada
Centre Hospitalier Regional Universitaire de Brest - Hopital de la Cavale Blanche
🇫🇷Brest, France
Dr. Syed Anees Medicine Profession Corporation
🇨🇦Windsor, Ontario, Canada
Beijing Friendship Hospital Affiliated of Capital University of Medical Science
🇨🇳Beijing Shi, China
The Third Xiangya Hospital Of Central South University
🇨🇳Changsha, China
CHU Dijon Bourgogne Hôpital François Mitterand
🇫🇷Dijon, France
Hopital Avicenne
🇫🇷Bobigny, France
CHU Nice - Hôpital Pasteur 2
🇫🇷Nice, France
Praxis für Pneumologie Dr. Silke Mronga & Dr. Lukas Jerrentrup
🇩🇪Marburg, Germany
Hopital Louis Pradel
🇫🇷Bron, France
Fakultni nemocnice Brno
🇨🇿Brno, Czechia
Servie de Pneumologie et centre de Transplantation Pulmonaire
🇫🇷Marseille, France
Fakultni Nemocnice; Interni Klinika - odd. Invazivni Kardiologie
🇨🇿Hradec Kralove, Czechia
Thomayerova nemocnice; Lekarna - pavilon H
🇨🇿Praha 4, Czechia
Gentofte Hospital
🇩🇰Hellerup, Denmark
Odense Universitetshospital
🇩🇰Odense C, Denmark
Ospedale San Giuseppe; U.O. di Pneumologia
🇮🇹Milano, Lombardia, Italy
Ospedale San Gerardo
🇮🇹Monza, Lombardia, Italy
Fondazione IRCCS Policlinico San Matteo Divisione di EmatologiaDipartimento di Onco-Ematologia
🇮🇹Pavia, Lombardia, Italy
A.O.U. Sassari; Dip. Medicina Clinica e Sperimentale
🇮🇹Sassari, Sardegna, Italy
Azienda Ospedaliero - Universitaria Policlinico - Vittorio Emanuele
🇮🇹Catania, Sicilia, Italy
Az. Osp. Univ. P. Giaccone; UOC di Pneumologia
🇮🇹Palermo, Sicilia, Italy
Ismett Istituto Mediterraneo Trapianti E Terapie Alta Specializzazione;Pneumologia
🇮🇹Palermo, Sicilia, Italy
University of Padova Ca' Foncello Hospital Immunologic & Respiratory Rare Diseases Center
🇮🇹Treviso, Veneto, Italy
AOUC Azienda Ospedaliero-Universitaria Careggi; Neurologia 2
🇮🇹Firenze, Toscana, Italy
University of Alabama at Birmingham
🇺🇸Birmingham, Alabama, United States
National Jewish Health Medical Center
🇺🇸Denver, Colorado, United States
Oregon Health and Science University
🇺🇸Portland, Oregon, United States
Mayo Clinic Rochester
🇺🇸Rochester, Minnesota, United States
Fukuoka University Hospital
🇯🇵Fukuoka, Japan
Kameda Medical Center
🇯🇵Kamogawa, Japan
Jichi Medical University Hospital
🇯🇵Tochigi, Japan
National Hospital Organization Kinki-Chuo Chest Medical Center
🇯🇵Sakai-shi, Japan
Tenri Hospital
🇯🇵Tenri-Shi, Japan
Center Hospital of the National Center for Global Health and Medicine
🇯🇵Tokyo, Japan
Hopital Bichat Claude Bernard; Hepatologie Gastro Enterologie
🇫🇷Paris, France
Hospital Universitario del Henares
🇪🇸Coslada, Madrid, Spain
Hospital Universitario de Bellvitge
🇪🇸Hospitalet de Llobregat, Barcelona, Spain
Hosp. Clinico San Carlos
🇪🇸Madrid, Spain
University of Nebraska Medical Center
🇺🇸Omaha, Nebraska, United States
Georgetown University Medical Center
🇺🇸Washington, District of Columbia, United States
Advanced Pulmonary & Sleep Research Institute of Florida
🇺🇸Daytona Beach, Florida, United States
Cairns Base Hospital; Cancer Care Centre
🇦🇺Cairns, Queensland, Australia
Princess Alexandra Hospital
🇦🇺Woolloongabba, Queensland, Australia
Florida Pulmonary Research Institute, LLC
🇺🇸Winter Park, Florida, United States
Florida Lung, Asthma and Sleep Specialists (FLASS) - Celebration
🇺🇸Celebration, Florida, United States
University of Florida Health Pulmonology - Jacksonville
🇺🇸Jacksonville, Florida, United States
Fundacion Respirar (Centro Medico Dra. De Salvo)
🇦🇷Ciudad Autonoma Buenos Aires, Argentina
Centro de estudios respiratorios
🇦🇷Mar Del Plata, Argentina
Centrum Medycyny Oddechowej Mroz sp. j.
🇵🇱Bia?ystok, Poland
ULB Hôpital Erasme
🇧🇪Brussels, Belgium
Cliniques Universitaires Saint-Luc; Pharmacy
🇧🇪Bruxelles, Belgium
The Alfred Hospital
🇦🇺Prahan, Victoria, Australia
Lung Research Queensland
🇦🇺Nundah, Queensland, Australia
The Second Xiangya Hospital of Central South University
🇨🇳Changsha, China
C.I.C. Mauricie
🇨🇦Trois-Rivières, Quebec, Canada
The First Affiliated Hospital of Zhengzhou University
🇨🇳Zhengzhou, China
CHU de Grenoble - Hôpital André Michallon; Pole Pharmacie
🇫🇷La Tronche, France
Tianjin Medical University General Hospital
🇨🇳Tianjin, China
University General Hospital of Heraklion
🇬🇷Heraklio, Greece
Policlinico Riuniti di Foggia - Department of Medical and Surgical Sciences - University of Foggia
🇮🇹Foggia, Puglia, Italy
Azienda Ospedale Universita Di Padova; Divisione Clinicizzata Di Nefrologia 1
🇮🇹Padova, Veneto, Italy
A.O. Univ. Senese Policlinico S. Maria alle Scotte; Dip. Medicina clinica e Scienze Immunologiche
🇮🇹Siena, Toscana, Italy
Kanagawa Cardiovascular and Respiratory Center
🇯🇵Kanagawa, Japan
Kurashiki Central Hospital
🇯🇵Okayama, Japan
Saiseikai Kumamoto Hospital
🇯🇵Kumamoto-Shi, Japan
Tokyo Medical Ando Dentaluni Hospital Faculty of Medicine; Surgical Oncology
🇯🇵Tokyo, Japan
The Catholic University of Korea Bucheon St. Mary's Hospital
🇰🇷Gyeonggi-do, Korea, Republic of
Gacheon University Gil Medical Center
🇰🇷Namdong-gu, Korea, Republic of
Seoul National University Hospital (SNUH) - Medical Oncology Center
🇰🇷Seoul, Korea, Republic of
INER- Instituto Nacional de Enfermedades Respiratorias"Ismae
🇲🇽Ciudad de México, Mexico CITY (federal District), Mexico
Soonchunhyang University Hospital
🇰🇷Seoul, Korea, Republic of
Unidad de Investigacion CIMA SC
🇲🇽Chihuahua, Mexico
Waikato Hospital; Gastro Research
🇳🇿Hamilton, New Zealand
NZ Respiratory & Sleep Institute
🇳🇿Auckland, New Zealand
Akershus universitetssykehus
🇳🇴Lørenskog, Norway
Oslo University Hospital HF, Rikshospitalet
🇳🇴Oslo, Norway
Centro Hospitalar Universitario Lisboa Norte - Hospital Pulido Valente
🇵🇹Lisboa, Portugal
Corporació Sanitaria Parc TaulÃ; Servicio de NeurologÃa
🇪🇸Sabadell, Barcelona, Spain
Hospital Galdakao-Usansolo
🇪🇸Galdakao, Vizcaya, Spain
Hospital Clinic I Provincial
🇪🇸Barcelona, Spain
Clinica Universidad de Navarra ; Servicio de Farmacia
🇪🇸Madrid, Spain
Universidad Autonoma de Madrid (UAM) - Hospital Universitario La Paz
🇪🇸Madrid, Spain
Hospital Universitario 12 de Octubre
🇪🇸Madrid, Spain
Hospital Clinico Universitario de Salamanca
🇪🇸Salamanca, Spain
Buddhist Tzu Chi Dalin General Hospital; Rheumatology
🇨🇳Chia-yi, Taiwan
National Cheng Kung University Hospital
🇨🇳Tainan, Taiwan
National Taiwan University Hospital
🇨🇳Taipei, Taiwan
Istanbul Universitesi Onkoloji Enstitüsü Hastanesi
🇹🇷?stanbul, Turkey
Cukurova Universitesi Tip Fakultesi Balcali Hastanesi; Balcali
🇹🇷Adana, Turkey
Ankara Universitesi Tip Fakultesi Hastaneleri - Cebeci Hastanesi
🇹🇷Ankara, Turkey
Uludag Universitesi - Saglik Uygulama ve Arastirrma Merkezi
🇹🇷Bursa, Turkey
Gaziantep Universitesi Tip Fakultesi
🇹🇷Gaziantep, Turkey
Yedikule Gogus Hastaliklari ve Gogus Cerrahisi Egitim ve Arastirma Hastanesi
🇹🇷Istanbul, Turkey
Ege Universitesi Tip Fakultesi Hastanesi
🇹🇷Izmir, Turkey
Marmara Universitesi Hastanesi Marmara University Hospital
🇹🇷Maltepe, Turkey
Eriyes universitesi T?p Fakultesi Hastanesi
🇹🇷Melikgazi/Kayser, Turkey
Mersin Universitesi Tip Fakultesi Hastanesi; Tibbi Onkoloji Birimi
🇹🇷Mersin, Turkey
Akdeniz University Faculty of Medicine Department of Pulmonology
🇹🇷Muratpasa/Antalya, Turkey
Asan Medical Center
🇰🇷Seoul, Korea, Republic of
Tudogyogyintezet Torokbalint; Onkologiai és Jarobeteg Centrum
ðŸ‡ðŸ‡ºTörökbálint, Hungary
UZ Leuven
🇧🇪Leuven, Belgium
Unidad Médica para la Salud Integral UMSI
🇲🇽San Nicolás de Los Garza, Nuevo LEON, Mexico
SPZOZ Uniwersytecki Szpital Kliniczny nr 1 im. Norberta Barlickiego Uniwersytetu Medycznego w Lodzi
🇵🇱Lodz, Poland
Helse Bergen HF Haukeland universitetssykehus; Hudavdelingen
🇳🇴Bergen, Norway
China Medical University Hospital
🇨🇳Taichung, Taiwan
Far Eastern Memorial Hospital; Department of Clinical Pathology
🇨🇳Taipei, Taiwan
University of California Davis
🇺🇸Sacramento, California, United States
Virginia Commonwealth University
🇺🇸Richmond, Virginia, United States
Yale New Haven Hospital
🇺🇸New Haven, Connecticut, United States
University of Louisville Health Sciences Center
🇺🇸Louisville, Kentucky, United States
Renstar Medical Research
🇺🇸Wesley Chapel, Florida, United States
Ospedale Morgagni Pierantoni; Patologia clinica
🇮🇹Forlì, Emilia-Romagna, Italy
University of Kansas Medical Center
🇺🇸Kansas City, Kansas, United States
The University of Hong Kong; Queen Mary Hospital
ðŸ‡ðŸ‡°Hong Kong, Hong Kong