Short-term Health Benefits of Using Fresh Air Filtration System in Classroom

Not Applicable

Completed

• Conditions: Airway Morbidity; Oxidative Stress; Cognitive and Attention Disorders and Disturbances
• Interventions: Device: Fresh air system with filtration

• Registration Number: NCT03788330
• Lead Sponsor: Fudan University

Brief Summary

A randomized crossover trial will be conducted in 90 primary school children in 3 classrooms in Shanghai, China. The effects of fresh air ventilation/filtration system, fresh air ventilation system with no filtration and natual ventilation will be compared on the effects of reducing indoor PM2.5 and chilhood health. Biological samples of children are going to be collected to investigate the associations between indoor air pollution and biomarkes of certain health effects.

Detailed Description

A randomized crossover trial among 90 primary students in 3 classrooms in Shanghai, China will be performed. Three arms are going to be 1) fresh air filtration system, 2) fresh air system with no filtration and 3) natural ventilation. Each arm is going to be in use for five continuous weekdays followed by one week of wash-out. After one-week of wash out, a cross over change between 3 arms is going to be taked. Then the 2nd week of intervention is performed followed by the 2nd wash-out week. The same cross-over change between 3 arms is going to be repeated again until each classroom will be applied by all three arms of ventilation. A total of 5 weeks is required for the project. Children's biological samples including saliva, urine and skin samples will be collected as well as exhaled NO. A questionnaire on children's perception on air quality will be assessed as well.

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study First Submitted: 2018-12-05
• Study Start: 2018-12-07
• Study First Submitted QC: 2018-12-25
• Study First Posted: 2018-12-27
• Primary Completion: 2019-01-20
• Study Completion: 2019-01-22
• Status Verified: 2019-03
• Last Update Submitted: 2019-03-28
• Last Update Posted: 2019-03-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 94

Inclusion Criteria

• All invited primary school children in Grade 5 in an artibrarily selected school

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Exclusion Criteria

• Current airway symptoms (cough, airway infection, asthma et al.)
• Acute infectious diseases

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Fresh air system with filtration	Fresh air system with filtration	A fresh air ventilation system combined with PM2.5 filtration is applied in one primary school classroom.
Fresh air system with no filtration	Fresh air system with filtration	A fresh air ventilation system with no PM2.5 filtration is applied in a parallel classroom.

Primary Outcome Measures

Name	Time	Method
Exhaled nitric oxide	within 2 hours of the end of intervention in each week	Airway inflammation biomarker
Oxidative stress biomarkers	within 2 hours of the end of intervention in each week	The level of lysozyme, cortisone and SIgA will be assessed in saliva and other oxidative biomarkers in the urine samples in children.
Sick building symdrom	within 2 hours of the end of intervention in each week	Answering questionnaire on sick biulding symdrom

Trial Locations

Locations (1)

Fudan University; 🇨🇳 Shanghai, China