Comparison of two drugs named dexmedetomidine and ketamine during general anesthesia (state of unconsciousnessor asleep) in brain surgeries for maintenance of blood pressure, heart rate, depth of sleep and pain control during surgery and post surgery pain management intervention.

Not yet recruiting

Brief Summary: The goals of Neuroanaesthesia are to ensure stable perioperative stable hemodynamics and avoid sudden rise in intracranial pressure (ICP) to prevent acute brain swelling. Craniotomy is associated with intense surgical stimuli causing sympathetic activation which results in marked changes in systemic arterial pressure and cerebral blood flow and hence raised ICP and reduction in cerebral perfusion leading to cerebral ischemia especially in patients with impaired cereberal autoregulation. Hence prevention and control of nociceptive stimulus are of utmost importance. Dexmedetomidine is alpha 2 agonist having sedative, anxiolytic, analgesic and sympatholytic properties. Ketamine is N - methyl D- Aspartate antagonist producing sedation, catalepsy, somatic analgesia and snympathetic nerve stimulation. This comparison studies aim to assess efficacy of these drugs on intraoperative hemodynamic stability, requirements of other anaesthetic agents, emergence, assessment of postoperative pain and side effects.

Recruitment & Eligibility

Inclusion Criteria

1 Patients aged 18.
65 years. 2 American Society of Anesthesiologists I/II. 3 Elective supratentorial craniotomy.

Exclusion Criteria

1 Known allergy to drugs.
2 History of renal,liver, cerebrovascular and cardiovascular (mod/severe) disease.
3 Chronic beta blocker treatment with heart rate or preoperative HR< 50/min.
4 Isolated frontal lobe surgery.

Primary Outcome Measures

Name	Time	Method
Hemodynamic parameters - Mean arterial pressure( MAP)	Baseline values will be recorded (average of 3) prior to start of study drug. At 0,5 and 10 mins hemodynamic parameters and BIS are recorded. Then at induction , intubation and incision. In between recordings at 15 min interval. At stopping study drug and starting atracurium. Followed by stopping atracurium and tapering propofol. Again recordings will be taken at emergence and extubation

Secondary Outcome Measures

Name	Time	Method
Hemodynamic parameter SBP and DBP, HR, BIS	Requirement of other annaetshetic drugs propofol, atracurium.

Locations (1): Paras Hospital
🇮🇳
Gurgaon, HARYANA, India
Paras Hospital
🇮🇳Gurgaon, HARYANA, India
Dr Ankita Jaiswal
Principal investigator
8527500275
ankita772@gmail.com