Effects of resuscitation with sodium bicarbonate on cardiac function in patients with early-phase septic shock

Completed

• Conditions: Cardiac functions in patients with early-phase septic shock; Signs and Symptoms; Septic shock

• Registration Number: ISRCTN36748319
• Lead Sponsor: The Second Hospital of Nanjing, affiliated with Medical College, Southeast University (China)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2006-06-13
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

Patents with early phase septic shock (according to the criteria of the American College of Chest Physicians/Society of Critical Care Medicine). The criteria for inclusion is fulfilment of two out of the four criteria for the systemic inflammatory response syndrome (SIRS) and a systolic blood pressure lower than 90 mmHg or a reduction of 40 mm Hg from baseline.

Exclusion Criteria

Patients with a myocardial infarction, hemorrhagic shock, trauma, pregnancy, do-not-attempt-resuscitation orders, or immediate surgery requirement are excluded.
In order to focus the study on the subject of early phase septic shock, the patients with last-phase septic shock characterized by coma, seizure, diffusing intravascular coagulation (DIC), pulmonary edema and anuria on admission were rejected.
The cases treated with vasopressors, inotropic agents and mechanical ventilation during the initial two hours or with death imminent within 24 hours were also rejected.

Study & Design

• Study Type: Interventional
• Study Design: Not specified