Effect of a Physical Exercise Session Performed During a 24-34 Hour Fasting Period on Energy Metabolism and Cognitive Function in Healthy Adults

Not Applicable

Recruiting

• Conditions: Energy Metabolism
• Interventions: Behavioral: 34-hour fasting in sedentary conditions; Behavioral: 34-hour fasting with high-intensity exercise

• Registration Number: NCT05919979
• Lead Sponsor: Universidad de Granada

Brief Summary

This study explores the impact of high-intensity exercise during fasting on energy metabolism and cognitive function in healthy adults. Changes in respiratory exchange ratio, blood substances, and cognitive performance will be measured after 24 and 34 hours of fasting with and without exercise in a randomized crossover design.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-05-29
• Study First Submitted: 2023-06-05
• Study First Submitted QC: 2023-06-15
• Study First Posted: 2023-06-27
• Status Verified: 2024-05
• Last Update Submitted: 2025-01-30
• Last Update Posted: 2025-02-03
• Primary Completion: 2025-12-31
• Study Completion: 2025-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• 18-40 years old.
• Body mass index: 18.5-30.0 Kg/m2.
• Stable body weight (5kg range within the last 3 months)
• Being able to consume all the food items provided as part of the study.
• Not having change the time zone or have shifted sleeping hours equivalent to more than 3 hours on the previous 2 weeks.

Exclusion Criteria

• Diagnosed with any chronic condition that, in the research team's opinion or based on the American College of Sports Medicine guidelines, could contraindicate the implementation of 34-hour fasting periods and/or high-intensity exercise.
• Diagnosed with a chronic endocrine, digestive, rheumatic, neurological, cardiac, pulmonary, autoimmune, or infectious condition that affects energy metabolism.
• Presenting any signs or symptoms of illness that, in the research team's opinion or based on the American College of Sports Medicine guidelines, could contraindicate the implementation of 34-hour fasting periods and/or high-intensity exercise.
• Pregnant or breastfeeding.
• Using medications or supplements that may alter energy metabolism.
• Currently undergoing or having undergone any type of nutritional intervention or treatment in the past 3 months.
• Engaging in more than 5 hours per week of habitual moderate-to-vigorous cycling.
• Any other condition that, in the research team's opinion, discourages participation in the study.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Fasting, then fasting+exercise	34-hour fasting in sedentary conditions	-
Fasting, then fasting+exercise	34-hour fasting with high-intensity exercise	-
Fasting + Exercise, then fasting	34-hour fasting in sedentary conditions	-
Fasting + Exercise, then fasting	34-hour fasting with high-intensity exercise	-

Primary Outcome Measures

Name	Time	Method
Respiratory Exchange Ratio	24-hour after starting the fasting period

Secondary Outcome Measures

Name	Time	Method
Respiratory Exchange Ratio	34-hour after starting the fasting period
Dimensional Change Card Sort Test (NIH toolbox)	34-hour after starting the fasting period
List Sorting Working Memory Test (NIH toolbox)	34-hour after starting the fasting period
Serum insulin concentration	34-hour after starting the fasting period
Serum glucose concentration	34-hour after starting the fasting period
Flanker Test (NIH toolbox)	34-hour after starting the fasting period

Trial Locations

Locations (1)

Instiuto Mixto Universitario Deporte y Salud; 🇪🇸 Granada, Spain