ung ultrasound to understand response to treatment in premature infants who have breathing difficulty due to lung immaturity
Not Applicable
Completed
- Conditions
- Health Condition 1: P220- Respiratory distress syndrome of newborn
- Registration Number
- CTRI/2023/07/055318
- Lead Sponsor
- Dr Anup Thakur
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 73
Inclusion Criteria
Preterm neonates = 34 weeks gestational age, who need respiratory support within 6 hours of birth will be included.
Exclusion Criteria
The following neonates will be excluded from the study:
1. Gestational age less than 26 weeks.
2. Extramural neonates.
3. Suspected chromosomal anomalies or major congenital malformations.
4. Suspected meconium aspiration syndrome or congenital pneumonia.
5. Neonates who receive surfactant in delivery room.
6. Neonates who are hemodynamically unstable and require inotropes.
7. Neonates who need extensive delivery room resuscitation such as chest compression and or medications.
8. Failure to obtain parental consent.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Predictive ability of lung USG score for response to surfactant replacement therapy in preterm neonates less than 34 weeks with respiratory distress syndrome requiring respiratory support within 6 hours of birth.Timepoint: within 6 hours of life
- Secondary Outcome Measures
Name Time Method 1. Lung USG score to identify neonates who would need FiO2 more than 0.30 in first 6 hours of life. <br/ ><br>2. Lung USG score for successful extubation in first 72 hours of life. <br/ ><br>3. Lung USG score for successful discontinuation of non-invasive ventilation (CPAP or HHHFNC) in first week of life. <br/ ><br>4.Lung USG scores pre-surfactant & 6 hours post surfactant replacement therapy. <br/ ><br>5. Lung USG score & oxygenation indices pre-surfactant & 6 hours post surfactant replacement therapy. <br/ ><br>Timepoint: first 7 days of life